2-Oxoindoline-5-sulfonamide

Base Information

• Chemical Name: 2-Oxoindoline-5-sulfonamide
• CAS No.: 175075-24-8
• Molecular Formula: C₈H₈N₂O₃S
• Molecular Weight: 212.229
• Hs Code.: 2935009090
• DSSTox Substance ID: DTXSID20436660
• Mol file: 175075-24-8.mol

Synonyms:175075-24-8;2-oxoindoline-5-sulfonamide;2,3-DIHYDRO-2-OXO-1H-INDOLE-5-SULFONAMIDE;2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide;2-oxo-2,3-dihydro-1H-indole-5-sulfonamide;2-oxo-1,3-dihydroindole-5-sulfonamide;1H-Indole-5-sulfonamide, 2,3-dihydro-2-oxo-;5-Aminosulfonyl-2-Ox-Indole;5-Aminosulfonyl-2-oxindole;5-Aminosulfonyl-2-indolinone;oxindole-5-sulfonamide;5-aminosulphonyloxindole;5-sulfamoyl-2-oxindole;5-aminosulfonylindolin-2-one;SCHEMBL689168;DTXSID20436660;PJRWVQFEVVSTKZ-UHFFFAOYSA-N;MFCD05844462;AKOS000149701;SB65747;CS-0120637;FT-0666996;EN300-41204;J-011059;Z57729911

Chemical Property of 2-Oxoindoline-5-sulfonamide

Chemical Property:

• PKA: 9.82±0.20(Predicted)
• PSA: 97.64000
• Density: 1.516g/cm3
• LogP: 1.74770
• Solubility.: Dichloromethane, DMSO, THF
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 212.02556330
• Heavy Atom Count: 14
• Complexity: 346

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dihydro-2-oxo-1H-indole-5-sulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2=C(C=CC(=C2)S(=O)(=O)N)NC1=O
• Uses: 2,3-Dihydro-2-oxo-1H-indole-5-sulfonamide (cas# 175075-24-8) is a compound useful in organic synthesis.

Technology Process of 2-Oxoindoline-5-sulfonamide

There total 8 articles about 2-Oxoindoline-5-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methanolic ammonia + 2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride (199328-31-9) → 5-aminosulfonyl-2-oxindole (175075-24-8)

Guidance literature:

In ethanol; dichloromethane;

Reference yield: 21.0%

2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride (199328-31-9) → 5-aminosulfonyl-2-oxindole (175075-24-8)

Guidance literature:

With ammonia; In methanol; at 20 ℃;

Reference yield: 20.0%

2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride (199328-31-9) → 3-(3-methyl-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide + 5-aminosulfonyl-2-oxindole (175075-24-8)

Guidance literature:

With ammonium hydroxide; In ethanol;

upstream raw materials:

2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid

2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride

2-oxoindole

Downstream raw materials:

3-(1H-indol-3-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide

SyK inhibitor