Bicyclo[3.1.0]hexan-3-one

Base Information

• Chemical Name: Bicyclo[3.1.0]hexan-3-one
• CAS No.: 1755-04-0
• Molecular Formula: C6H8O
• Molecular Weight: 96.1289
• Mol file: 1755-04-0.mol

Synonyms:3-oxobicyclo[3.1.0]hexane acid;Bicyclo(3.1.0)hexanon-(3);(13C(1))-3-Bicyclo(3.1.0)hexanon;bicyclo(3.1.0)hexan-3-one;Bicyclo[3.1.0]hexan-3-on;(13C(2))-3-Bicyclo(3.1.0)hexanon;

Chemical Property of Bicyclo[3.1.0]hexan-3-one

Chemical Property:

• Boiling Point: 54-55 °C(Press: 25 Torr)
• PSA: 17.07000
• Density: 1.144±0.06 g/cm3(Predicted)
• LogP: 0.98540
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Cis-bicyclo[3.1.0]hexan-3-one 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Bicyclo[3.1.0]hexan-3-one

There total 15 articles about Bicyclo[3.1.0]hexan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(1R,3r,5S)-bicyclo[3.1.0]hexan-3-ol (694-43-9,89489-26-9) → bicyclo[3.1.0]hexan-3-one (1755-04-0)

Guidance literature:

With chromic acid; In diethyl ether; for 3h; Ambient temperature;

DOI:10.1021/jm00403a014

Reference yield: 80.0%

bicyclo[3.1.0]hexane-3-ol (89489-26-9) → bicyclo[3.1.0]hexan-3-one (1755-04-0)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

(1R,5S)-bicyclo[3.1.0]hexan-3-ol (89489-26-9) → bicyclo[3.1.0]hexan-3-one (1755-04-0)

Guidance literature:

With pyridine; pyridinium chlorochromate; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

(1R,3r,5S)-bicyclo[3.1.0]hexan-3-ol

3-Methylen-bicyclo<3.1.0>hexan

(1R,5S)-bicyclo[3.1.0]hexan-3-ol

cyclopent-3-enol

Downstream raw materials:

trans-3-phenylbicyclo<3.1.0>hexan-3-ol

1,4-Pentadiene

bicyclo[3.1.0]hexane-3-ol

Refernces

• 1、 -. "N-SUBSTITUTED-4-OXO-3,4-DIHYDROPYRIDO[2,3-D]PYRIMIDIN-2-YL DERIVATIVES AS INHIBITORS OF THE HUMAN IMMUNODEFICIENCY VIRUS REPLICATION". Page/Page column 25. . Retrieved 2021/04/10.
• 2、 -. "N-SUBSTUTUTED-6-OXO-1,6-DIHYDROPYRIMIDINE-2-YL DERIVATIVES AS INHIBITORS OF THE HUMAN IMMUNODEFICIENCY VIRUS REPLICATION". Page/Page column 17. . Retrieved 2021/04/10.