2-(3-Methoxyphenyl)thiophene

Base Information

• Chemical Name: 2-(3-Methoxyphenyl)thiophene
• CAS No.: 17595-93-6
• Molecular Formula: C11H10OS
• Molecular Weight: 190.266
• DSSTox Substance ID: DTXSID70393693
• Nikkaji Number: J546.197I
• Wikidata: Q82192565
• Mol file: 17595-93-6.mol

Synonyms:2-(3-methoxyphenyl)thiophene;17595-93-6;3-(2-Thienyl)anisole;SCHEMBL22280;DTXSID70393693;JLSBMXUYHUFHTH-UHFFFAOYSA-N;AKOS004114027;BB 0222682

Chemical Property of 2-(3-Methoxyphenyl)thiophene

Chemical Property:

• PSA: 37.47000
• LogP: 3.42370
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 190.04523611
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

5-(3-METHOXY PHENYL)THIOPHENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)C2=CC=CS2

Technology Process of 2-(3-Methoxyphenyl)thiophene

There total 17 articles about 2-(3-Methoxyphenyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-methoxy-1-iodobenzene (766-85-8) + 2-thienylzinc bromide (45438-80-0) → 2-(3-methoxyphenyl)thiophene (17595-93-6)

Guidance literature:

(4-F⁽¹³⁾C₆-C₆H₄)3P; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 60 ℃;

DOI:10.1002/anie.199726231

Reference yield: 98.0%

2-bromo-5-(3-methoxyphenyl)thiophene (1078734-14-1) → 2-(3-methoxyphenyl)thiophene (17595-93-6)

Guidance literature:

2-bromo-5-(3-methoxyphenyl)thiophene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

With water; In tetrahydrofuran; hexane;

DOI:10.1021/jm8006917

Reference yield: 96.0%

2-bromothiophene (1003-09-4) + 3-methoxyphenylboronic acid (10365-98-7,1107579-37-2) → 2-(3-methoxyphenyl)thiophene (17595-93-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; at 100 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jm101073q

upstream raw materials:

thiophene

3-methoxy-1-iodobenzene

2-thienyl lithium

2-methoxyphenyl mesylate

Downstream raw materials:

2-(3'-hydroxyphenyl)thiophene

(3-methoxy-4-methylphenyl)[5-(3-methoxyphenyl)-2-thienyl]methanone

(3-methoxy-4-nitrophenyl)[5-(3-methoxyphenyl)-2-thienyl]methanone

(3-methoxyphenyl)[5-(3-methoxyphenyl)-2-thienyl]methanone