Technology Process of Benzaldehyde, 4-hydroxy-5-methoxy-2-methyl-3-nitro-
There total 2 articles about Benzaldehyde, 4-hydroxy-5-methoxy-2-methyl-3-nitro- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 57 percent / TiCl4 / CH2Cl2 / 1 h / Ambient temperature
2: 61 percent / HNO3, AcOH / tetrahydrofuran / 1 h / Ambient temperature
With
nitric acid; titanium tetrachloride; acetic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/0223-5234(96)89134-3
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) NaH / 1.) DMF, 0 deg C, 15 min, 2.) DMF, 60 deg C, 1 h
2: 94 percent / NaH2PO4, NaClO2 / H2O; dimethylsulfoxide / 0.5 h / Ambient temperature
3: 88 percent / K2CO3 / dimethylformamide / 12 h / Ambient temperature
4: pyrrolidine / dimethylformamide / 6 h / Heating
5: 19 percent / Zn, 80percent aq. CH3COOH / 85 °C
6: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 30 min
7: H2 / 10percent Pd/C / ethyl acetate; H2O / 5 h / 760 Torr
With
pyrrolidine; sodium chlorite; sodium dihydrogenphosphate; hydrogen; sodium hydride; potassium carbonate; acetic acid; zinc;
palladium on activated charcoal;
In
water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(96)89134-3