(2-(Diphenylphosphino)phenyl)methanamine

Base Information

• Chemical Name: (2-(Diphenylphosphino)phenyl)methanamine
• CAS No.: 177263-77-3
• Molecular Formula: C19H18NP
• Molecular Weight: 291.332
• European Community (EC) Number: 863-339-0
• DSSTox Substance ID: DTXSID50455945
• Nikkaji Number: J824.642D
• Wikidata: Q82278122
• Mol file: 177263-77-3.mol

Synonyms:(2-(Diphenylphosphino)phenyl)methanamine;177263-77-3;(2-diphenylphosphanylphenyl)methanamine;Benzenemethanamine, 2-(diphenylphosphino)-;2-(Diphenylphosphino)benzenemethanamine;2-(Diphenylphosphino)benzylamine;AGN-PC-0NG7IN;SCHEMBL12700939;DTXSID50455945;CHA26377;(2-(diphenylphosphanyl)phenyl)methanamine;CS-0108738;D94575

Chemical Property of (2-(Diphenylphosphino)phenyl)methanamine

Chemical Property:

• PSA: 39.61000
• LogP: 3.60380
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 291.117686576
• Heavy Atom Count: 21
• Complexity: 276

Purity/Quality:

97% ^*data from raw suppliers

(2-(Diphenylphosphino)phenyl)methanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(C2=CC=CC=C2)C3=CC=CC=C3CN

Technology Process of (2-(Diphenylphosphino)phenyl)methanamine

There total 10 articles about (2-(Diphenylphosphino)phenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-fluorobenzylamine (89-99-6) + potassium diphenylphosphine (15475-27-1,4346-39-8) → (2-(diphenylphosphanyl)phenyl)methanamine (177263-77-3)

Guidance literature:

In 1,2-dimethoxyethane; at 85 ℃; for 24h;

DOI:10.1002/(SICI)1099-0682(199801)1998:1<73::AID-EJIC73>3.0.CO;2-M

Reference yield: 94.0%

2-(diphenylphosphanyl)benzonitrile (34825-99-5) → (2-(diphenylphosphanyl)phenyl)methanamine (177263-77-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 4h; Heating;

DOI:10.1016/S0957-4166(98)00393-0

Reference yield:

N-benzyl(trimethylsilyl)amine (14856-79-2) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → (2-(diphenylphosphanyl)phenyl)methanamine (177263-77-3)

Guidance literature:

With n-butyllithium; In diethyl ether; at -35 - 20 ℃;

DOI:10.1039/c5ra19304d

upstream raw materials:

2-(diphenylphosphanyl)benzonitrile

2-fluorobenzylamine

potassium diphenylphosphine

2-fluorobenzonitrile

Downstream raw materials:

[2-(anilinomethyl)phenyl]diphenylphosphine

tert-butyl (S)-2-((2-(diphenylphosphino)phenyl)methylcarbamoyl)pyrrolidine-1-carboxylate

(2-diphenylphosphanylbenzyl)pyrid-2-ylmethyl amine