3-METHYL-PIPERIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 3-METHYL-PIPERIDINE HYDROCHLORIDE
• CAS No.: 58531-29-6
• Molecular Formula: C6H13 N . Cl H
• Molecular Weight: 0
• Hs Code.: 2933399090
• Mol file: 58531-29-6.mol

Synonyms:Piperidine,3-methyl-, hydrochloride (9CI); 3-Methylpiperidine hydrochloride; NSC 203094

Chemical Property of 3-METHYL-PIPERIDINE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 125.5°Cat760mmHg
• Flash Point: 17.2°C
• PSA: 12.03000
• Density: 0.809g/cm³
• LogP: 2.13670

Purity/Quality:

99%min ^*data from raw suppliers

3-METHYL-PIPERIDINE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHYL-PIPERIDINE HYDROCHLORIDE

There total 5 articles about 3-METHYL-PIPERIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-picoline-N-oxide (1003-73-2) → 3-methylpiperidinehydrochloride (58531-29-6,155797-02-7)

Guidance literature:

3-picoline-N-oxide; With ammonium formate; 10percent palladium on carbon; In methanol; at 20 ℃; for 16h;

With hydrogenchloride; In methanol; Further stages.;

DOI:10.1021/jo015649g

Reference yield: 91.0%

2-methylglutaronitrile (4553-62-2) → 3-methylpiperidinehydrochloride (58531-29-6,155797-02-7)

Guidance literature:

2-methylglutaronitrile; With C₄₆H₁₇₈O₄₁Si₄₂; titanium(IV)isopropoxide; In toluene; at 100 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; water; In toluene; at 20 ℃; for 4h; chemoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2013.11.101

Reference yield: 78.0%

2-methylcadaverine (15520-10-2) → 3-methylpiperidinehydrochloride (58531-29-6,155797-02-7)

Guidance literature:

2-methylcadaverine; With 5 wt% ruthenium/carbon; aluminium; In water; at 150 ℃; for 2.5h;

With hydrogenchloride; In dichloromethane;

DOI:10.1016/j.tet.2009.12.025

upstream raw materials:

1,2-dimethyl-3-(3-methylpiperidino)-5-phenylpyrazolium chloride

3-Methylpiperidine

3-picoline-N-oxide

2-methylcadaverine

Downstream raw materials:

3-(3'-methylpiperidino)-1-phenyl-propan-1-one

Refernces

• 1、 G?dda, Thomas M.,Yu, Xiao-Yan,Miyazawa, Akira. "Ru/C catalyzed cyclization of linear α,ω-diamines to cyclic amines in water". experimental part. p. 1249 - 1253. Retrieved 2010/03/30.
• 2、 Cross,Arotin,Ruopp. "Pyrazoles by dealkylation of pyrazolium salts". . p. 905 - 910. Retrieved 2007/10/02.