Benzenesulfonamide, 4-[2-(2-methyl-3-pyridinyl)-4-(trifluoromethyl)-1H-imidazol-1-yl]-

Base Information

Chemical Name:Benzenesulfonamide, 4-[2-(2-methyl-3-pyridinyl)-4-(trifluoromethyl)-1H-imidazol-1-yl]-
CAS No.:177660-94-5
Molecular Formula:C16H13F3N4O2S
Molecular Weight:382.366
Hs Code.:

Synonyms:

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Chemical Property of Benzenesulfonamide, 4-[2-(2-methyl-3-pyridinyl)-4-(trifluoromethyl)-1H-imidazol-1-yl]-

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Technology Process of Benzenesulfonamide, 4-[2-(2-methyl-3-pyridinyl)-4-(trifluoromethyl)-1H-imidazol-1-yl]-

There total 12 articles about Benzenesulfonamide, 4-[2-(2-methyl-3-pyridinyl)-4-(trifluoromethyl)-1H-imidazol-1-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 177662-71-4
2-methyl-3-[1-[4-[[2-(trimethylsilyl)-ethyl]sulfonyl]phenyl]-4-(trifluoromethyl)-1H-imidazol-2-yl]pyridine

: 177660-94-5
4-[2-(2-methyl-pyridin-3-yl)-4-trifluoromethyl-imidazol-1-yl]-benzenesulfonamide

Guidance literature:: 2-methyl-3-[1-[4-[[2-(trimethylsilyl)-ethyl]sulfonyl]phenyl]-4-(trifluoromethyl)-1H-imidazol-2-yl]pyridine; With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h; Heating / reflux;

With sodium acetate; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; water; at 20 ℃; for 1h;

Reference yield: 78.0%

: 3-[1-[4-[(2,5-dimethyl-1H-pyrrol-1-yl)sulfonyl]phenyl]-4-(trifluoromethyl)-1H-imidazol-2-yl]-2-methylpyridine

: 177660-94-5
4-[2-(2-methyl-pyridin-3-yl)-4-trifluoromethyl-imidazol-1-yl]-benzenesulfonamide

Guidance literature:: With trifluoroacetic acid; In water; for 2h; Heating / reflux;

Reference yield:

: 3222-56-8
2-methylnicotinic acid

: 177660-94-5
4-[2-(2-methyl-pyridin-3-yl)-4-trifluoromethyl-imidazol-1-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: CH₂Cl₂ / 20 °C

2.1: NH₃(g) / CH₂Cl₂ / 1 h / 20 °C

3.1: 75 percent / trifluoroacetic anhydride; Et₃N / CH₂Cl₂ / 0 °C

4.1: sodium bis(trimethylsilyl) amide / tetrahydrofuran / 4 h / 25 °C

4.2: tetrahydrofuran / 4 h

5.1: NaHCO₃ / propan-2-ol / 4.5 h / 50 - 80 °C

6.1: p-toluenesulfonic acid monohydrate / toluene / 4 h / Heating

7.1: oxone / H₂O; methanol / 20 °C

8.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C

8.2: tetrahydrofuran; hexane / -78 - 20 °C

9.1: tetrabutylammonium fluoride / tetrahydrofuran / 1 h / Heating

9.2: aq. NaOAc; hydroxylamine-O-sulfonic acid / tetrahydrofuran / 1 h / 20 °C

With Oxone; tetrabutyl ammonium fluoride; ammonia; sodium hexamethyldisilazane; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic anhydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; isopropyl alcohol; toluene; 1.1: Condensation / 2.1: Substitution / 3.1: Dehydration / 4.1: deprotonation / 4.2: Addition / 5.1: Alkylation / 6.1: Dehydration / 7.1: Oxidation / 8.1: Metallation / 8.2: Alkylation / 9.1: Elimination / 9.2: Substitution;
DOI:10.1021/jm0000719