Phosphonic acid, [hydroxy(4-nitrophenyl)methyl]-, diethyl ester

Base Information

• Chemical Name: Phosphonic acid, [hydroxy(4-nitrophenyl)methyl]-, diethyl ester
• CAS No.: 1776-87-0
• Molecular Formula: C11H16NO6P
• Molecular Weight: 289.225
• Mol file: 1776-87-0.mol

Synonyms:diethyl [hydroxy(4-nitrophenyl)methyl]phosphonate;diethyl (hydroxy)(4-nitrophenyl)methylphosphonate;diethyl α-hydroxy-4-nitrobenzylphosphonate;(α-hydroxy-4-nitro-benzyl)-phosphonic acid diethyl ester;[hydroxy-(4-nitro-phenyl)-methyl]-phosphonic acid diethyl ester;diethyl hydroxy(4-nitrophenyl)methylphosphonate;

Chemical Property of Phosphonic acid, [hydroxy(4-nitrophenyl)methyl]-, diethyl ester

Chemical Property:

• Melting Point: 85 °C (ethanol)
• PSA: 111.39000
• LogP: 3.37500

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphonic acid, [hydroxy(4-nitrophenyl)methyl]-, diethyl ester

There total 6 articles about Phosphonic acid, [hydroxy(4-nitrophenyl)methyl]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-nitrobenzaldehdye (555-16-8) + phosphonic acid diethyl ester (762-04-9) → diethyl (hydroxy(4-nitrophenyl)methyl)phosphonate (1776-87-0)

Guidance literature:

With magnesium oxide; for 0.17h;

DOI:10.1080/00397919708003324

Reference yield: 96.0%

4-nitrobenzaldehdye (555-16-8) + triethyl phosphite (122-52-1) → diethyl (hydroxy(4-nitrophenyl)methyl)phosphonate (1776-87-0)

Guidance literature:

With iodine; In water; at 80 ℃; for 0.333333h;

DOI:10.1080/10426500903061541

Reference yield: 95.0%

Diethyl phosphonate (762-04-9,123-22-8) + 4-nitrobenzaldehdye (555-16-8) → diethyl (hydroxy(4-nitrophenyl)methyl)phosphonate (1776-87-0)

Guidance literature:

Diethyl phosphonate; With [(Me₃Si)₂N]₃La(μ-Cl)Li(THF)₃; In toluene; for 0.166667h; Inert atmosphere;

4-nitrobenzaldehdye; In toluene; at 25 ℃; for 0.0833333h; Inert atmosphere;

DOI:10.1021/jo101743e

upstream raw materials:

4-nitrobenzaldehdye

phosphonic acid diethyl ester

triethyl phosphite

diethyl trimethylsilyl phosphite

Downstream raw materials:

diethyl 4-nitrobenzoyl phosphonate

diethyl [(4-nitrophenyl)(phenylamino)methyl]phosphonate

(4-{[6-(3-aminophenyl)pyrimidin-4-yl]amino}benzyl)phosphonic acid

(4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}benzyl)phosphonic acid