4-(5-FORMYL-2-FURYL)BENZOIC ACID

Base Information

• Chemical Name: 4-(5-FORMYL-2-FURYL)BENZOIC ACID
• CAS No.: 39245-15-3
• Molecular Formula: C12H8 O4
• Molecular Weight: 216.193
• Hs Code.: 2932190090
• Mol file: 39245-15-3.mol

Synonyms:4-(5-Formyl-2-furyl)benzoicacid; 4-(5-Formylfuran-2-yl)benzoic acid; 5-(4-Carboxyphenyl)-2-furaldehyde;5-(4-Carboxyphenyl)furfural

Chemical Property of 4-(5-FORMYL-2-FURYL)BENZOIC ACID

Chemical Property:

• Vapor Pressure: 1.35E-08mmHg at 25°C
• Boiling Point: 442.1°Cat760mmHg
• Flash Point: 221.2°C
• PSA: 67.51000
• Density: 1.336g/cm³
• LogP: 2.45730
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-(5-formyl-2-furyl)benzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(5-FORMYL-2-FURYL)BENZOIC ACID

There total 8 articles about 4-(5-FORMYL-2-FURYL)BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-(5-formyl-2-furanyl)benzoic acid methyl ester (53355-29-6) → 4-(5'-formylfuran-2'-yl)benzoic acid (39245-15-3)

Guidance literature:

With methanol; water; lithium hydroxide; Reflux; Inert atmosphere;

DOI:10.1016/j.bioorg.2021.105518

Reference yield: 90.0%

5-bromo-2-furancarboxaldehyde (1899-24-7) + 4-carboxyphenylboronic acid (14047-29-1) → 4-(5'-formylfuran-2'-yl)benzoic acid (39245-15-3)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; palladium diacetate; In water; at 20 - 25 ℃; for 12h;

Reference yield: 90.0%

→ 4-(5'-formylfuran-2'-yl)benzoic acid (39245-15-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 90 ℃; for 15h; Inert atmosphere;

upstream raw materials:

furfural

4-amino-benzoic acid

5-formylfurane-2-boronic acid

4-iodobenzoic acid

Downstream raw materials:

2-(4-carboxyphenyl)-5-(6-cyanobenzothiazol-2-yl)furan

4-{5-[3-(2,4-Dichloro-phenyl)-2-[(Z)-2,4-dichloro-phenylimino]-4-oxo-thiazolidin-(5E)-ylidenemethyl]-furan-2-yl}-benzoic acid

4-{5-[3-(4-Fluoro-phenyl)-2-[(Z)-4-fluoro-phenylimino]-4-oxo-thiazolidin-(5E)-ylidenemethyl]-furan-2-yl}-benzoic acid

4-{5-[3-(2-Nitro-phenyl)-2-[(Z)-2-nitro-phenylimino]-4-oxo-thiazolidin-(5E)-ylidenemethyl]-furan-2-yl}-benzoic acid