1H-Pyrazole-4-carboxylic acid, 3-(1,1-dimethylethyl)-1-propyl-5-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl] [1,1'-biphenyl]-4-yl]methyl]-, methyl ester

Base Information

Chemical Name:1H-Pyrazole-4-carboxylic acid, 3-(1,1-dimethylethyl)-1-propyl-5-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl] [1,1'-biphenyl]-4-yl]methyl]-, methyl ester
CAS No.:177847-19-7
Molecular Formula:C45H44N6O2
Molecular Weight:700.883
Hs Code.:

1H-Pyrazole-4-carboxylic acid,
3-(1,1-dimethylethyl)-1-propyl-5-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl]
[1,1'-biphenyl]-4-yl]methyl]-, methyl ester

Synonyms:

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Chemical Property of 1H-Pyrazole-4-carboxylic acid, 3-(1,1-dimethylethyl)-1-propyl-5-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl] [1,1'-biphenyl]-4-yl]methyl]-, methyl ester

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Technology Process of 1H-Pyrazole-4-carboxylic acid, 3-(1,1-dimethylethyl)-1-propyl-5-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl] [1,1'-biphenyl]-4-yl]methyl]-, methyl ester

There total 4 articles about 1H-Pyrazole-4-carboxylic acid, 3-(1,1-dimethylethyl)-1-propyl-5-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl] [1,1'-biphenyl]-4-yl]methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 143722-25-2
2-(2'-Triphenylmethyl-2'H-tetrazol-5'-yl)-phenylboronic acid

: 177847-18-6
methyl 5-(4-bromophenylmethyl)-3-tert-butyl-1-propyl-1H-pyrazole-4-carboxylate

: 177847-19-7
methyl 3-tert-butyl-1-propyl-5-[[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-1H-pyrazole-4-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; In 1,2-dimethoxyethane; at 100 ℃;
DOI:10.1021/jm9604383

Reference yield: 75.0%

: 177847-19-7
methyl 3-tert-butyl-1-propyl-5-[[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-1H-pyrazole-4-carboxylate

Guidance literature:

Reference yield:

: 177847-16-4
methyl 2-(4-bromophenylacetyl)-3-tert-butyl-3-oxopropanoate

: 177847-19-7
methyl 3-tert-butyl-1-propyl-5-[[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / NH₂NH₂*H₂O, AcOH / 18 h / Ambient temperature

2: 78 percent / 72 h / Heating

3: 85 percent / CsF, Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrazine hydrate; acetic acid; cesium fluoride; In 1,2-dimethoxyethane;
DOI:10.1021/jm9604383