1,3-Dihydro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-2H-1,4-benzodiazepin-2-one

Base Information

Chemical Name:1,3-Dihydro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-2H-1,4-benzodiazepin-2-one
CAS No.:93592-73-5
Molecular Formula:C21H22 F N3 O
Molecular Weight:351.424
Hs Code.:
ChEMBL ID:CHEMBL159313
DSSTox Substance ID:DTXSID30918301

Synonyms:1,3-Dihydro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-2H-1,4-benzodiazepin-2-one;93592-73-5;2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-;CHEMBL159313;SCHEMBL10971871;DTXSID30918301;DBJUQQIMRVGVCC-UHFFFAOYSA-N;1-(1-methyl-4-piperidinyl)-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzdiazepin-2-one;5-(2-Fluorophenyl)-1-(1-methylpiperidin-4-yl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Suppliers and Price of 1,3-Dihydro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-2H-1,4-benzodiazepin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3-Dihydro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-2H-1,4-benzodiazepin-2-one

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:351.17469050
Heavy Atom Count:26
Complexity:543

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC(CC1)N2C(=O)CN=C(C3=CC=CC=C32)C4=CC=CC=C4F

Technology Process of 1,3-Dihydro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-2H-1,4-benzodiazepin-2-one

There total 2 articles about 1,3-Dihydro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-2H-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93592-83-7
2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-N-[2-(2-fluoro-benzoyl)-phenyl]-N-(1-methyl-piperidin-4-yl)-acetamide

: 93592-73-5
1,3-dihydro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-2H-1,4-benzodiazepin-2-one

Guidance literature:: With hydrazine hydrate; In ethanol; for 2h; Yield given; Heating;
DOI:10.1021/jm00383a003

Reference yield:

: 93593-09-0
(2-Fluoro-phenyl)-[2-(1-methyl-piperidin-4-ylamino)-phenyl]-methanone

: 93592-73-5
1,3-dihydro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / Ambient temperature

2: 80percent NH₂NH₂*H₂O / aq. ethanol / 2 h / Heating

With hydrazine hydrate; In ethanol; acetonitrile;
DOI:10.1021/jm00383a003