1-tert-butyl 4-ethyl 3-hydroxy-1H-pyrazole-1,4- dicarboxylate

Base Information

• Chemical Name: 1-tert-butyl 4-ethyl 3-hydroxy-1H-pyrazole-1,4- dicarboxylate
• CAS No.: 178424-17-4
• Molecular Formula: C11H16N2O5
• Molecular Weight: 256.25500
• Hs Code.: 2933199090
• Mol file: 178424-17-4.mol

Synonyms:1-tert-Butyl 4-ethyl 3-hydroxy-1H-pyrazole-1,4-dicarboxylate;1-tert-butyl 4-ethyl 3-hydroxy-1H-pyrazole-1,4-ndicarboxylate;

Chemical Property of 1-tert-butyl 4-ethyl 3-hydroxy-1H-pyrazole-1,4- dicarboxylate

Chemical Property:

• PSA: 90.65000
• LogP: 1.54860
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1-tert-Butyl4-ethyl3-hydroxy-1H-pyrazole-1,4-dicarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-tert-butyl 4-ethyl 3-hydroxy-1H-pyrazole-1,4- dicarboxylate

There total 3 articles about 1-tert-butyl 4-ethyl 3-hydroxy-1H-pyrazole-1,4- dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-hydroxypyrazole-4-carboxylic acid ethyl ester (7251-53-8) → 1-(tert-butyl) 4-ethyl 3-hydroxy-1H-pyrazole-1,4-dicarboxylate (178424-17-4)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

diethyl 2-ethoxymethylenemalonate (87-13-8) → 1-(tert-butyl) 4-ethyl 3-hydroxy-1H-pyrazole-1,4-dicarboxylate (178424-17-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 0 - 80 °C

2: triethylamine / dichloromethane / 20 °C

With hydrazine hydrate; triethylamine; In ethanol; dichloromethane;

Reference yield:

diethyl 2-ethoxymethylenemalonate (87-13-8) → 1-(tert-butyl) 4-ethyl 3-hydroxy-1H-pyrazole-1,4-dicarboxylate (178424-17-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NH₂NH₂, 2) NaOH / 2) H₂O

2: Et₃N / CH₂Cl₂

With sodium hydroxide; triethylamine; hydrazine; In dichloromethane;

DOI:10.1016/0960-894X(96)00165-5

upstream raw materials:

di-tert-butyl dicarbonate

3-hydroxypyrazole-4-carboxylic acid ethyl ester

diethyl 2-ethoxymethylenemalonate

Downstream raw materials:

3-[[(4-methoxyphenyl)methyl]oxy]pyrazole-4-carboxylic acid ethyl ester

ethyl 3-methoxy-1H-pyrazole-4-carboxylate

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