1-(5-methyl-1H-imidazol-4-yl)propan-2-amine

Base Information

• Chemical Name: 1-(5-methyl-1H-imidazol-4-yl)propan-2-amine
• CAS No.: 82977-50-2
• Molecular Formula: C₇H₁₃N₃
• Molecular Weight: 139.2
• Mol file: 82977-50-2.mol

Synonyms:1H-Imidazole-4-ethanamine,a,5-dimethyl- (9CI);1H-Imidazole-4-ethanamine, a,5-dimethyl-, (?à)-; (?à)-4-(2-Aminopropyl)-5-methylimidazole

Chemical Property of 1-(5-methyl-1H-imidazol-4-yl)propan-2-amine

Chemical Property:

• Vapor Pressure: 9.53E-05mmHg at 25°C
• Boiling Point: 338.9°C at 760 mmHg
• Flash Point: 185.4°C
• Density: 1.065g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-methyl-1H-imidazol-4-yl)propan-2-amine

There total 4 articles about 1-(5-methyl-1H-imidazol-4-yl)propan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-(2-Brompropyl)-5-methyl-imidazol (82935-14-6) → 1-(5-methyl-1H-imidazol-4-yl)-2-propanamine (82977-50-2)

Guidance literature:

With ammonium hydroxide; ammonium chloride; at 0 ℃; for 24h;

DOI:10.1002/ardp.19823150804

Reference yield:

2-amino-3-(5-methyl-1H-imidazol-4-yl)propanol dihydrochloride → 1-(5-methyl-1H-imidazol-4-yl)-2-propanamine (82977-50-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 61.5 percent / SOCl₂ / tetrahydrothiophene 1,1-dioxide / 12 h / Ambient temperature

2: NaOAc, AcOH, H₂ / 10percent Pd/C / 240 h / Ambient temperature

With thionyl chloride; hydrogen; sodium acetate; acetic acid; palladium on activated charcoal; In sulfolane;

DOI:10.1016/0223-5234(96)88228-6

Reference yield:

1-chloro-3-(5-methyl-1H-imidazol-4-yl)-2-propanamine dihydrochloride → 1-(5-methyl-1H-imidazol-4-yl)-2-propanamine (82977-50-2)

Guidance literature:

With hydrogen; sodium acetate; acetic acid; palladium on activated charcoal; for 240h; Ambient temperature;

DOI:10.1016/0223-5234(96)88228-6

upstream raw materials:

4-(2-Brompropyl)-5-methyl-imidazol