N-[(1R)-2-Hydroxy-1-phenylethyl]-4,5-dimethoxy-2-(3,4,5-trimethoxybenzoyl)benzeneacetamide

Base Information

Chemical Name:N-[(1R)-2-Hydroxy-1-phenylethyl]-4,5-dimethoxy-2-(3,4,5-trimethoxybenzoyl)benzeneacetamide
CAS No.:180072-41-7
Molecular Formula:C₂₈H₃₁NO₈
Molecular Weight:509.556
Hs Code.:
DSSTox Substance ID:DTXSID701122381
Mol file:180072-41-7.mol

Synonyms:DTXSID701122381;180072-41-7;N-[(1R)-2-Hydroxy-1-phenylethyl]-4,5-dimethoxy-2-(3,4,5-trimethoxybenzoyl)benzeneacetamide

Suppliers and Price of N-[(1R)-2-Hydroxy-1-phenylethyl]-4,5-dimethoxy-2-(3,4,5-trimethoxybenzoyl)benzeneacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(1R)-2-Hydroxy-1-phenylethyl]-4,5-dimethoxy-2-(3,4,5-trimethoxybenzoyl)benzeneacetamide

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:12
Exact Mass:509.20496695
Heavy Atom Count:37
Complexity:700

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)C(=O)C2=CC(=C(C=C2CC(=O)NC(CO)C3=CC=CC=C3)OC)OC
Isomeric SMILES:COC1=CC(=CC(=C1OC)OC)C(=O)C2=CC(=C(C=C2CC(=O)N[C@@H](CO)C3=CC=CC=C3)OC)OC

Technology Process of N-[(1R)-2-Hydroxy-1-phenylethyl]-4,5-dimethoxy-2-(3,4,5-trimethoxybenzoyl)benzeneacetamide

There total 3 articles about N-[(1R)-2-Hydroxy-1-phenylethyl]-4,5-dimethoxy-2-(3,4,5-trimethoxybenzoyl)benzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 56613-80-0
D-2-phenylglycinol

: 180072-40-6
[4,5-Dimethoxy-2-(3,4,5-trimethoxy-benzoyl)-phenyl]-acetic acid

: 180072-41-7
2-[4,5-Dimethoxy-2-(3,4,5-trimethoxy-benzoyl)-phenyl]-N-((R)-2-hydroxy-1-phenyl-ethyl)-acetamide

Guidance literature:: With 2,3,4,5,6-pentafluorophenol; dicyclohexyl-carbodiimide; for 18h; Ambient temperature;
DOI:10.1016/0040-4039(96)00819-2

Reference yield:

: 15964-79-1
methyl (3,4-dimethoxyphenyl)acetate

: 180072-41-7
2-[4,5-Dimethoxy-2-(3,4,5-trimethoxy-benzoyl)-phenyl]-N-((R)-2-hydroxy-1-phenyl-ethyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / PCl₅, AlCl₃ / CH₂Cl₂ / 48 h / then saponofication

2: 70 percent / DCC, C₆F₅OH / 18 h / Ambient temperature

With aluminium trichloride; 2,3,4,5,6-pentafluorophenol; phosphorus pentachloride; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/0040-4039(96)00819-2

Reference yield:

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 180072-41-7
2-[4,5-Dimethoxy-2-(3,4,5-trimethoxy-benzoyl)-phenyl]-N-((R)-2-hydroxy-1-phenyl-ethyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / PCl₅, AlCl₃ / CH₂Cl₂ / 48 h / then saponofication

2: 70 percent / DCC, C₆F₅OH / 18 h / Ambient temperature

With aluminium trichloride; 2,3,4,5,6-pentafluorophenol; phosphorus pentachloride; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/0040-4039(96)00819-2