3-chloro-4-Methoxyphenol

Base Information

• Chemical Name: 3-chloro-4-Methoxyphenol
• CAS No.: 18093-12-4
• Molecular Formula: C7H7ClO2
• Molecular Weight: 158.584
• Hs Code.: 2909500090
• Mol file: 18093-12-4.mol

Synonyms:Phenol,3-chloro-4-methoxy;3-Chlor-4-methoxy-phenol;2-CHLORO-4-HYDROXYANISOLE;3-chloro-4-methoxy phenol;

Chemical Property of 3-chloro-4-Methoxyphenol

Chemical Property:

• PSA: 29.46000
• LogP: 2.05420
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

3-Chloro-4-methoxyphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-chloro-4-Methoxyphenol

There total 12 articles about 3-chloro-4-Methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-chloro-4-methoxyphenylboronic acid pinacol ester → 3-chloro-4-methoxyphenol (18093-12-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In ethanol; water; at 20 ℃; for 3.5h;

DOI:10.1021/acs.orglett.7b00840

Reference yield: 69.2%

2-chloro-4-nitroanisole (4920-79-0) → 3-chloro-4-methoxyphenol (18093-12-4) + 2-chloro-4-nitrophenol (619-08-9) + 5-nitroguaiacol (636-93-1)

Guidance literature:

With water; sodium hydroxide; In acetonitrile; at 25 ℃; Temperature; regioselective reaction; Kinetics; Irradiation; Inert atmosphere;

DOI:10.1021/jo400367c

Reference yield: 67.0%

2-Chloroanisole (766-51-8) → 3-chloro-4-methoxyphenol (18093-12-4)

Guidance literature:

With dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; trifluoroacetic anhydride; at 80 ℃; for 6h;

upstream raw materials:

3-chloro-4-methoxyphenyl benzoate

4-methoxy-phenol

1,4-dimethoxybezene

3-chloro-4-methoxyaniline

Downstream raw materials:

4-Chloro-2-hydroxy-5-methoxy-benzaldehyde

3-chloro-4-methoxyaniline

3-chloro-4,4-dimethoxycyclohexa-2,5-dien-1-one

C₁₆H₁₇ClO₅

Refernces

• 1、 -. "Synthetic method 4 - alkoxyphenol compounds". Paragraph 0088-0090. . Retrieved 2021/09/29.
• 2、 Massignan, Leonardo,Tan, Xuefeng,Meyer, Tjark H.,Kuniyil, Rositha,Messinis, Antonis M.,Ackermann, Lutz. "C?H Oxygenation Reactions Enabled by Dual Catalysis with Electrogenerated Hypervalent Iodine Species and Ruthenium Complexes". supporting information. p. 3184 - 3189. Retrieved 2020/01/24.