3-Quinolinecarboxylic acid, 6,8-difluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-1-(2-phenyl-1- aziridinyl)-, ethyl ester

Base Information

Chemical Name:3-Quinolinecarboxylic acid, 6,8-difluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-1-(2-phenyl-1- aziridinyl)-, ethyl ester
CAS No.:181426-99-3
Molecular Formula:C25H26F2N4O3
Molecular Weight:468.503
Hs Code.:
Mol file:181426-99-3.mol

Synonyms:

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Chemical Property of 3-Quinolinecarboxylic acid, 6,8-difluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-1-(2-phenyl-1- aziridinyl)-, ethyl ester

Chemical Property:

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Technology Process of 3-Quinolinecarboxylic acid, 6,8-difluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-1-(2-phenyl-1- aziridinyl)-, ethyl ester

There total 4 articles about 3-Quinolinecarboxylic acid, 6,8-difluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-1-(2-phenyl-1- aziridinyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 181427-31-6
1-Amino-6,8-difluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

: 181426-99-3
6,8-Difluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(2-phenyl-aziridin-1-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: With lead(IV) acetate; In dichloromethane; at 25 ℃; for 12h;
DOI:10.3987/COM-97-7770

Reference yield:

: 109-01-3
1-methyl-piperazine

: 181426-99-3
6,8-Difluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(2-phenyl-aziridin-1-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / pyridine / 2 h / 130 °C

2: 42 percent / Pb(OAc)4 / CH₂Cl₂ / 12 h / 25 °C

With lead(IV) acetate; In pyridine; dichloromethane;
DOI:10.3987/COM-97-7770

Reference yield:

: 79660-46-1
ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

: 181426-99-3
6,8-Difluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-(2-phenyl-aziridin-1-yl)-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / K₂CO₃, O-(p-toluenesulfonyl)hydroxylamine / dimethylformamide; CH₂Cl₂ / 24 h / 25 °C

2: 61 percent / pyridine / 2 h / 130 °C

3: 42 percent / Pb(OAc)4 / CH₂Cl₂ / 12 h / 25 °C

With lead(IV) acetate; O-tosylhydroxylamine; potassium carbonate; In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-97-7770