COX-2 Inhibitor II

Base Information

Chemical Name:COX-2 Inhibitor II
CAS No.:181696-33-3
Molecular Formula:C16H12F2N2O3S
Molecular Weight:350.34000
Hs Code.:
DSSTox Substance ID:DTXSID30437825
Mol file:181696-33-3.mol

Synonyms:COX-2 Inhibitor II;181696-33-3;Benzenesulfonamide, 4-[5-(difluoromethyl)-3-phenyl-4-isoxazolyl]-;4-(5-(Difluoromethyl)-3-phenylisoxazol-4-yl)benzenesulfonamide;SCHEMBL214781;DTXSID30437825;DVSOGWILWKEIDD-UHFFFAOYSA-N;J-011614

Suppliers and Price of COX-2 Inhibitor II

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 9 raw suppliers

Chemical Property of COX-2 Inhibitor II

Chemical Property:

PSA：94.57000
LogP:5.37470
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:350.05366975
Heavy Atom Count:24
Complexity:512

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=NOC(=C2C3=CC=C(C=C3)S(=O)(=O)N)C(F)F
Clinical Use Celecoxib has been approved for the treatment of osteoarthritis and rheumatoid arthritis, and rofecoxib has been approved for the treatment of osteoarthritis, acute pain and primary dysmenorrhea. Celecoxib and rofecoxib do not appear to differ in efficacy for the treatment of osteoarthritis. However, neither drug has efficacy greater than that of the non-selective NSAIDs. Since the COX-2 enzyme appears to play an important role in colon cancer the COX-2 inhibitors may find future uses in the treatment or prevention of colorectal cancer.

Technology Process of COX-2 Inhibitor II

There total 3 articles about COX-2 Inhibitor II which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: