(S)-N-(1-(4-broMophenyl)ethyl)-2,2,2-trifluoroacetaMide

Base Information

• Chemical Name: (S)-N-(1-(4-broMophenyl)ethyl)-2,2,2-trifluoroacetaMide
• CAS No.: 182141-70-4
• Molecular Formula: C10H9BrF3NO
• Molecular Weight: 296.087
• Hs Code.: 2924299090
• Mol file: 182141-70-4.mol

Synonyms:N-[(1S)-1-(4-BROMOPHENYL)ETHYL]-2,2,2-TRIFLUOROACETAMIDE;bromophenethylamine trifluoroacetamide;(S)-N-(1-(4-bromophenyl)ethyl)-2,2,2-trifluoroacetamide;N-[(S)-(4-bromo-phenyl)-ethyl]-2,2,2-trifluoro-acetamide;

Chemical Property of (S)-N-(1-(4-broMophenyl)ethyl)-2,2,2-trifluoroacetaMide

Chemical Property:

• Boiling Point: 344.9±42.0 °C(Predicted)
• PKA: 10.44±0.46(Predicted)
• PSA: 29.10000
• Density: 1.522±0.06 g/cm3(Predicted)
• LogP: 3.57950
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

N-[(1S)-1-(4-Bromophenyl)ethyl]-2,2,2-trifluoroacetamide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-N-(1-(4-broMophenyl)ethyl)-2,2,2-trifluoroacetaMide

There total 6 articles about (S)-N-(1-(4-broMophenyl)ethyl)-2,2,2-trifluoroacetaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(S)-1-(4-bromophenyl)ethylamine (27298-97-1) + trifluoroacetic anhydride (407-25-0) → N-[(1S)-1-(4-bromophenyl)ethyl]-2,2,2-trifluoroacetamide (182141-70-4,871720-04-6)

Guidance literature:

With triethylamine; In acetonitrile; at 5 ℃; for 1.5h; Temperature;

Reference yield: 58.5%

(S)-1-phenyl-ethylamine (2627-86-3) + trifluoroacetic anhydride (407-25-0) → N-[(1S)-1-(4-bromophenyl)ethyl]-2,2,2-trifluoroacetamide (182141-70-4,871720-04-6)

Guidance literature:

(S)-1-phenyl-ethylamine; trifluoroacetic anhydride; In dichloromethane; at 0 - 10 ℃; for 1h; Large scale;

With methanesulfonic acid; 5,5-dibromohydantoin; In dichloromethane; at 0 - 10 ℃; Large scale;

Reference yield:

(S)-2,2,2-trifluoro-(α-methylbenzyl)acetamide (2354-91-8,28332-81-2,39995-50-1,39995-51-2) → N-[(1S)-1-(4-bromophenyl)ethyl]-2,2,2-trifluoroacetamide (182141-70-4,871720-04-6)

Guidance literature:

With methanesulfonic acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1016/S0960-894X(02)00024-0

upstream raw materials:

(S)-2,2,2-trifluoro-(α-methylbenzyl)acetamide

(S)-1-(4-bromophenyl)ethylamine

trifluoroacetic anhydride

(S)-1-phenyl-ethylamine

Downstream raw materials:

2,2,2-trifluoro-N-{1-[4-(4-methoxy-benzenesulfonyl)-phenyl]-ethyl}-acetamide

2,2,2-trifluoro-N-{1-[4-(4-trifluoromethyl-benzenesulfonyl)-phenyl]-ethyl}-acetamide

N-{1-[4-(4-chloro-phenylsulfanyl)-phenyl]-ethyl}-2,2,2-trifluoro-acetamide

(S)-1-(4-bromophenyl)ethylamine

Refernces

• 1、 -. "Preparation method of optically pure 4-(1-amino) ethyl benzoate and salt thereof". Paragraph 0084-0088. . Retrieved 2021/03/30.
• 2、 -. "PYRIDYL-AZA(THIO)XANTHONE SENSITIZER COMPRISING LANTHANIDE(III) ION COMPLEXING COMPOUNDS, THEIR LUMINESCENT LANTHANIDE (III) ION COMPLEXES AND USE THEREOF AS FLUORESCENT LABELS.". Page/Page column 50; 51. . Retrieved 2010/08/08.