4-Methylthioamphetamine

Base Information

• Chemical Name: 4-Methylthioamphetamine
• CAS No.: 14116-06-4
• Molecular Formula: C₁₀H₁₅NS
• Molecular Weight: 181.302
• UNII: 6JP2T8KXTR
• DSSTox Substance ID: DTXSID90894854
• Nikkaji Number: J1.114.643K
• Wikipedia: 4-Methylthioamphetamine
• Wikidata: Q230013
• Pharos Ligand ID: 1R6MFJSH2XHZ
• ChEMBL ID: CHEMBL6467
• Mol file: 14116-06-4.mol

Synonyms:4-methylthioamphetamine;alpha-methyl-p-(methylthio)phenethylamine;p-methylthioamphetamine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 4-Methylthioamphetamine

Chemical Property:

• Vapor Pressure: 0.00226mmHg at 25°C
• Boiling Point: 289°C at 760 mmHg
• PKA: 9.96±0.10(Predicted)
• Flash Point: 128.6°C
• PSA: 51.32000
• Density: 1.04g/cm³
• LogP: 2.99850
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 181.09252066
• Heavy Atom Count: 12
• Complexity: 119

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(CC1=CC=C(C=C1)SC)N
• Description: 4-MTA is a methylthio analog of para-methoxyamphetamine (PMA), a hallucinogenic drug that has been scheduled in many countries. In animal models, the effects of 4-MTA are qualitatively and quantitatively indistinguishable from those of PMA. The metabolism of 4-METHYLTHIOAMPHETAMIN has recently been described. This product is intended for forensic applications.
• Uses: It is a potent non-neurotonic serotonin-releasing agent, and a potent, selective and reversible monoamine oxidase-A (MAO-A) inhibitor. 4-Methylthioamphetamine (4-MTA) belongs to a group of new amphetamine derivatives that is usually sold as "ecstasy" or "flatliners" on the illicit drug market.

Technology Process of 4-Methylthioamphetamine

There total 10 articles about 4-Methylthioamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-[4-(methylthio)phenyl]-2-propanone (88356-92-7) → 4-MTA (14116-06-4,756816-57-6,765898-09-7)

Guidance literature:

With hydrogenchloride; ammonium acetate; sodium cyanoborohydride; In methanol; at 20 ℃; for 72h; pH=5 - 6;

DOI:10.1016/j.ejmech.2009.07.027

Reference yield: 81.0%

1-(4-methylthiophenyl)-2-nitropropene → 4-MTA (14116-06-4,756816-57-6,765898-09-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 24h; Heating;

DOI:10.1081/SCC-120006041

Reference yield: 80.0%

1-[4-(methylthio)phenyl]-2-propanone (88356-92-7) → N,N-di(1-(4-methylthiophenyl)-2-propyl)amine (1236220-47-5) + 4-MTA (14116-06-4,756816-57-6,765898-09-7)

Guidance literature:

1-[4-(methylthio)phenyl]-2-propanone; With hydrogenchloride; ammonium acetate; sodium cyanoborohydride; In methanol; at 20 ℃; for 72h; pH=5 - 6;

With sodium hydroxide; In methanol; dichloromethane; water;

DOI:10.1016/j.bmc.2010.04.022

upstream raw materials:

1-(4-methylthiophenyl)-2-nitro-1-propene

Nitroethane

4-(Methylthio)benzaldehyde

1-[4-(methylthio)phenyl]-2-propanone

Downstream raw materials:

4-Methylthioamphetamine hydrochloride