Benzoic acid, 4-[(1S)-1,2-dihydroxyethyl]-, methyl ester

Base Information

Chemical Name:Benzoic acid, 4-[(1S)-1,2-dihydroxyethyl]-, methyl ester
CAS No.:183058-01-7
Molecular Formula:C₁₀H₁₂O₄
Molecular Weight:196.203
Hs Code.:
Mol file:183058-01-7.mol

Synonyms:

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Chemical Property of Benzoic acid, 4-[(1S)-1,2-dihydroxyethyl]-, methyl ester

Chemical Property:

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Technology Process of Benzoic acid, 4-[(1S)-1,2-dihydroxyethyl]-, methyl ester

There total 3 articles about Benzoic acid, 4-[(1S)-1,2-dihydroxyethyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1076-96-6
methyl 4-vinylbenzoate

: 183058-01-7
(S)-methyl 4-(1,2-dihydroxyethyl)benzoate

Guidance literature:: With potassium dioxotetrahydroxoosmate(VI); (DHQ)2-PHAL; potassium carbonate; potassium hexacyanoferrate(III); In water; tert-butyl alcohol;
DOI:10.3891/acta.chem.scand.50-0832

Reference yield:

: 1076-96-6
methyl 4-vinylbenzoate

: 183058-01-7
(S)-methyl 4-(1,2-dihydroxyethyl)benzoate

: (R)-methyl 4-(1,2-dihydroxyethyl)benzoate

Guidance literature:: With peracetic acid; trifluorormethanesulfonic acid; (2R,2'R)-2,2'-((2-iodo-5-methyl-1,3-phenylene)bis(oxy))bis(N-(2,6-diisopropylphenyl)propanamide); acetic acid; at 20 ℃; for 7h; enantioselective reaction;
DOI:10.1002/anie.201507180

Reference yield:

: 1571-08-0
methyl 4-formylbenzoate

: 183058-01-7
(S)-methyl 4-(1,2-dihydroxyethyl)benzoate

: (R)-methyl 4-(1,2-dihydroxyethyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: n-butyllithium / tetrahydrofuran; hexane / 16 h / 0 °C

2: acetic acid; peracetic acid; trifluorormethanesulfonic acid; (2R,2'R)-2,2'-((2-iodo-5-methyl-1,3-phenylene)bis(oxy))bis(N-(2,6-diisopropylphenyl)propanamide) / 7 h / 20 °C

With peracetic acid; n-butyllithium; trifluorormethanesulfonic acid; (2R,2'R)-2,2'-((2-iodo-5-methyl-1,3-phenylene)bis(oxy))bis(N-(2,6-diisopropylphenyl)propanamide); acetic acid; In tetrahydrofuran; hexane; 1: |Wittig Olefination;
DOI:10.1002/anie.201507180