Morphinan-3-ol, 6,7-didehydro-4,5-alpha-epoxy-17-methyl-8-beta-piperidino-

Base Information

• Chemical Name: Morphinan-3-ol, 6,7-didehydro-4,5-alpha-epoxy-17-methyl-8-beta-piperidino-
• CAS No.: 63783-55-1
• Molecular Formula: C22H28N2O2
• Molecular Weight: 352.47
• DSSTox Substance ID: DTXSID10213225
• Nikkaji Number: J70.108D
• Wikidata: Q76311100
• Mol file: 63783-55-1.mol

Synonyms:8-Piperidomorphide;Morphide, 8-piperidino-;BRN 0051607;63783-55-1;Morphinan-3-ol, 6,7-didehydro-4,5-alpha-epoxy-17-methyl-8-beta-piperidino-;4-27-00-05518 (Beilstein Handbook Reference);DTXSID10213225;LS-91945;6,7-Didehydro-4,5alpha-epoxy-17-methyl-8beta-piperidinomorphinan-3-ol;Morphinan-3-ol, 6,7-didehydro-4,5-epoxy-17-methyl-8-(1-piperidinyl)-, (5.alpha.,8.beta.)-

Chemical Property of Morphinan-3-ol, 6,7-didehydro-4,5-alpha-epoxy-17-methyl-8-beta-piperidino-

Chemical Property:

• Vapor Pressure: 1.47E-10mmHg at 25°C
• Boiling Point: 498.4°C at 760 mmHg
• Flash Point: 255.3°C
• PSA: 35.94000
• Density: 1.31g/cm³
• LogP: 2.56750
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 352.215078140
• Heavy Atom Count: 26
• Complexity: 603

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC23C4C=CC(C2C1CC5=C3C(=C(C=C5)O)O4)N6CCCCC6
• Isomeric SMILES: CN1CC[C@]23[C@@H]4C=C[C@@H]([C@H]2[C@H]1CC5=C3C(=C(C=C5)O)O4)N6CCCCC6

Technology Process of Morphinan-3-ol, 6,7-didehydro-4,5-alpha-epoxy-17-methyl-8-beta-piperidino-

There total 3 articles about Morphinan-3-ol, 6,7-didehydro-4,5-alpha-epoxy-17-methyl-8-beta-piperidino- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-O-acetylmorphine (5140-28-3) → 8-Piperidino-6-desoxy-Δ6-morphin (63783-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Py / 24 h / Ambient temperature

2: benzene / 3 h / Heating

With pyridine; In benzene;

DOI:10.1248/cpb.24.901

Reference yield:

piperidine (110-89-4) + 6β-chloro-4,5α-epoxy-17-methyl-morphin-7-en-3-ol (60048-94-4) → 8-Piperidino-6-desoxy-Δ6-morphin (63783-55-1)

Guidance literature:

DOI:10.1021/ja01877a062

Reference yield:

piperidine (110-89-4) + 3-O-acetyl-6-tosylmorphine (22864-80-8) → 8-Piperidino-6-desoxy-Δ6-morphin (63783-55-1)

Guidance literature:

In benzene; for 3h; Heating;

DOI:10.1248/cpb.24.901

upstream raw materials:

piperidine

6β-chloro-4,5α-epoxy-17-methyl-morphin-7-en-3-ol

3-O-acetyl-6-tosylmorphine

3-O-acetylmorphine