4-bromo-N-hydroxybenzamide

Base Information

• Chemical Name: 4-bromo-N-hydroxybenzamide
• CAS No.: 1836-27-7
• Molecular Formula: C7H6BrNO2
• Molecular Weight: 216.034
• Hs Code.: 2924299090
• Mol file: 1836-27-7.mol

Synonyms:4-bromobenzenecarbohydroxamic acid;p-Bromobenzohydroxamsaeure;Benzamide,4-bromo-N-hydroxy;4-bromobenzohydroxamic acid;4-Bromo-N-hydroxy-benzamide;4-Brom-benzohydroxamsaeure;p-Bromobenzohydroxamic acid;

Chemical Property of 4-bromo-N-hydroxybenzamide

Chemical Property:

• Melting Point: 185-186 °C(Solv: ethanol (64-17-5))
• PKA: 8?+-.0.10(Predicted)
• PSA: 49.33000
• Density: 1.701±0.06 g/cm3(Predicted)
• LogP: 1.95900

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromo-N-hydroxybenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-bromo-N-hydroxybenzamide

There total 11 articles about 4-bromo-N-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Bromobenzoic acid (586-76-5) → 4-bromo-N-hydroxybenzamide (1836-27-7)

Guidance literature:

4-Bromobenzoic acid; With 4-(Methylamino)pyridine; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃;

With hydroxylamine; In dichloromethane; water; at 20 ℃; Further stages.;

DOI:10.1016/j.tetlet.2007.12.073

Reference yield: 98.0%

4-methoxycarbonylphenyl bromide (619-42-1) → 4-bromo-N-hydroxybenzamide (1836-27-7)

Guidance literature:

With hydroxylamine hydrochloride; potassium hydroxide; In methanol; at 20 ℃; for 12h; pH=10;

DOI:10.1039/c6ob01178k

Reference yield: 98.0%

→ 4-bromo-N-hydroxybenzamide (1836-27-7)

Guidance literature:

With potassium hydroxide; hydroxylamine; In methanol; at 20 ℃; for 12h; pH=10;

DOI:10.1039/b822806j

upstream raw materials:

Ethyl 4-bromobenzoate

4-methoxycarbonylphenyl bromide

4-chlorobenzoyl chloride

4-Bromobenzoic acid

Downstream raw materials:

4c-[3-(4-bromo-phenyl)-5-methyl-[1,4,2]dioxazol-5-yl]-but-3-en-2-one

3-(4-Bromo-phenyl)-6,7a-dimethyl-4a,7a-dihydro-furo[3,2-e][1,4,2]dioxazine

2-p-bromobenzoyl-3-hydroxyisoxazolidine

(4-Bromo-phenyl)-(5-hydroxy-isoxazolidin-2-yl)-methanone

Refernces

• 1、 Yang, Zheng-Lin,Xu, Xin-Liang,Chen, Xue-Rong,Mao, Zhi-Feng,Zhou, Yi-Feng. "Silver-Catalyzed Acyl Nitrene Transfer Reactions Involving Dioxazolones: Direct Assembly of N-Acylureas". supporting information. p. 648 - 652. Retrieved 2020/12/21.
• 2、 Zhang, Xinyu,Lin, Bo,Chen, Jianhui,Chen, Jiajia,Luo, Yanshu,Xia, Yuanzhi. "Synthesis of sulfimides and N-Allyl-N-(thio)amides by Ru(II)catalyzed nitrene transfer reactions of N-acyloxyamides". supporting information. p. 819 - 825. Retrieved 2021/02/01.