2-Propenoic acid, 2-hydroxy-3-[[(1R,2S,5S)-1-[[2-[4-methoxy-3-(phenylmethoxy)phenyl]eth yl]amino]-2-methyl-5-(1-methylethyl)cyclohexyl]thio]-, methyl ester, (2E)-

Base Information

• Chemical Name: 2-Propenoic acid, 2-hydroxy-3-[[(1R,2S,5S)-1-[[2-[4-methoxy-3-(phenylmethoxy)phenyl]eth yl]amino]-2-methyl-5-(1-methylethyl)cyclohexyl]thio]-, methyl ester, (2E)-
• CAS No.: 184016-39-5
• Molecular Formula: C₃₀H₄₁NO₅S
• Molecular Weight: 527.725
• Mol file: 184016-39-5.mol

Synonyms:

Chemical Property of 2-Propenoic acid, 2-hydroxy-3-[[(1R,2S,5S)-1-[[2-[4-methoxy-3-(phenylmethoxy)phenyl]eth yl]amino]-2-methyl-5-(1-methylethyl)cyclohexyl]thio]-, methyl ester, (2E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenoic acid, 2-hydroxy-3-[[(1R,2S,5S)-1-[[2-[4-methoxy-3-(phenylmethoxy)phenyl]eth yl]amino]-2-methyl-5-(1-methylethyl)cyclohexyl]thio]-, methyl ester, (2E)-

There total 6 articles about 2-Propenoic acid, 2-hydroxy-3-[[(1R,2S,5S)-1-[[2-[4-methoxy-3-(phenylmethoxy)phenyl]eth yl]amino]-2-methyl-5-(1-methylethyl)cyclohexyl]thio]-, methyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-carvomenthone (13163-73-0) → (E)-3-{(1R,2S,5S)-1-[2-(3-Benzyloxy-4-methoxy-phenyl)-ethylamino]-5-isopropyl-2-methyl-cyclohexylsulfanyl}-2-hydroxy-acrylic acid methyl ester (184016-39-5)

Guidance literature:

Multi-step reaction with 2 steps

1: mol sieves (3 Angstroem) / toluene / 2 h / 55 °C

2: AcOH / 23 °C

With 3 A molecular sieve; acetic acid; In toluene;

DOI:10.1016/0040-4039(96)01622-X

Reference yield:

(E)-2-(benzyloxy)-1-methoxy-4-(2-nitrovinyl)benzene (63909-29-5) → (E)-3-{(1R,2S,5S)-1-[2-(3-Benzyloxy-4-methoxy-phenyl)-ethylamino]-5-isopropyl-2-methyl-cyclohexylsulfanyl}-2-hydroxy-acrylic acid methyl ester (184016-39-5)

Guidance literature:

Multi-step reaction with 3 steps

1: LiAlH₄ / tetrahydrofuran / 7 h / 23 °C

2: mol sieves (3 Angstroem) / toluene / 2 h / 55 °C

3: AcOH / 23 °C

With lithium aluminium tetrahydride; 3 A molecular sieve; acetic acid; In tetrahydrofuran; toluene;

DOI:10.1016/0040-4039(96)01622-X

Reference yield:

carvotanacetone (499-71-8) → (E)-3-{(1R,2S,5S)-1-[2-(3-Benzyloxy-4-methoxy-phenyl)-ethylamino]-5-isopropyl-2-methyl-cyclohexylsulfanyl}-2-hydroxy-acrylic acid methyl ester (184016-39-5)

Guidance literature:

Multi-step reaction with 3 steps

2: mol sieves (3 Angstroem) / toluene / 2 h / 55 °C

3: AcOH / 23 °C

With 3 A molecular sieve; acetic acid; In toluene;

DOI:10.1016/0040-4039(96)01622-X

upstream raw materials:

(-)-carvomenthone

(E)-2-(benzyloxy)-1-methoxy-4-(2-nitrovinyl)benzene

carvotanacetone

3-benzyloxy-4-methoxyphenylethylamine