ethyl 6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

• Chemical Name: ethyl 6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS No.: 185023-34-1
• Molecular Formula: C15H18N2O2S
• Molecular Weight: 290.386
• Mol file: 185023-34-1.mol

Synonyms:1,2,3,4-tetrahydro-6-methyl-4-(4-methylphenyl)-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester;ethyl 4-(4-methylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate;6-Methyl-2-thioxo-4-p-tolyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester;ethyl 6‐methyl‐4‐p‐tolyl‐2‐thioxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate;6-methyl-2-thioxo-4-p-tolyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester;ethyl 1,2,3,4-tetrahydro-6-methyl-2-thioxo-4-(4-methylphenyl)pyrimidine-5-carboxylate;

Chemical Property of ethyl 6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property:

• PSA: 82.45000
• LogP: 3.00850

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 7 articles about ethyl 6-methyl-2-thioxo-4-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methyl-benzaldehyde (104-87-0) + ethyl acetoacetate (141-97-9) + thiourea (17356-08-0) → 5-carboethoxy-6-methyl-4-(4-methylphenyl)-1H-pyrimidin-2-thione (185023-34-1)

Guidance literature:

With aluminium-planted mesoporous silica M₄₁ with Si/Al = 33; In octane; at 114.84 ℃; for 10h; Inert atmosphere;

DOI:10.1039/b920821f

Reference yield: 91.0%

4-methyl-benzaldehyde (104-87-0) + ethyl acetoacetate (141-97-9) + thiourea (17356-08-0) → 5-carboethoxy-6-methyl-4-(4-methylphenyl)-1H-pyrimidin-2-thione (185023-34-1)

Guidance literature:

In neat (no solvent); at 50 ℃; for 4h; Sealed tube; Inert atmosphere;

DOI:10.1039/c7dt04006g

Reference yield: 89.0%

→ 5-carboethoxy-6-methyl-4-(4-methylphenyl)-1H-pyrimidin-2-thione (185023-34-1)

Guidance literature:

With toluene-4-sulfonic acid; In ethylene glycol; at 50 ℃; for 16h;

upstream raw materials:

4-methyl-benzaldehyde

ethyl acetoacetate

thiourea

p-tolylmethylenediacetate

Downstream raw materials:

ethyl 3-amino-5-(4-methylphenyl)-2-cyano-7-methyl-5H-thiazolo[a-2,3]pyrimidine-6-carboxylate