2-(3-fluorophenyl)oxirane

Base Information

• Chemical Name: 2-(3-fluorophenyl)oxirane
• CAS No.: 18511-63-2
• Molecular Formula: C8H7FO
• Molecular Weight: 138.141
• Hs Code.: 2910900090
• Mol file: 18511-63-2.mol

Synonyms:3-fluorostyrene oxide;meta-fluorostyrene oxide;<3-Fluor-phenyl>-oxiran;

Chemical Property of 2-(3-fluorophenyl)oxirane

Chemical Property:

• Boiling Point: 187.6±28.0 °C(Predicted)
• PSA: 12.53000
• Density: 1.225±0.06 g/cm3(Predicted)
• LogP: 1.89700

Purity/Quality:

97% ^*data from raw suppliers

2-(3-fluorophenyl)oxirane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(3-fluorophenyl)oxirane is a reagent used in the preparation of mechanochemical aynthesis of 1,?2-?diketoindolizine derivatives. Also used in the preparation of styrene derivatives.

Technology Process of 2-(3-fluorophenyl)oxirane

There total 8 articles about 2-(3-fluorophenyl)oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

trimethylsulfoxonium iodide (1774-47-6) + 3-Fluorobenzaldehyde (456-48-4) → 3-fluorophenylethylene oxide (18511-63-2)

Guidance literature:

trimethylsulfoxonium iodide; With potassium tert-butylate; In tetrahydrofuran; dimethyl sulfoxide; at 40 ℃; for 1h;

3-Fluorobenzaldehyde; In tetrahydrofuran; dimethyl sulfoxide; at 0 ℃; for 0.5h;

Reference yield: 80.0%

trimethylsulphonium iodide (2181-42-2) + 3-Fluorobenzaldehyde (456-48-4) → 3-fluorophenylethylene oxide (18511-63-2)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; mineral oil; at 0 - 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1039/C8CC06503A

Reference yield: 54.3%

2-bromo-1-(3-fluorophenyl)ethanone (53631-18-8) → 3-fluorophenylethylene oxide (18511-63-2)

Guidance literature:

2-bromo-1-(3-fluorophenyl)ethanone; With sodium tetrahydroborate; In methanol; at 0 ℃;

With potassium carbonate;

DOI:10.1002/adsc.202000898

upstream raw materials:

3-fluorostyrene

trimethylsulfonium iodide

3-Fluorobenzaldehyde

trimethylsulfoxonium iodide

Downstream raw materials:

2-[2-(N,N-dimethylamino)ethoxy]-1-(3-fluorophenyl)ethanol hydrochloride

4-[2-(3-fluorophenyl)-2-hydroxyethoxy]benzaldehyde

(2R)-2-(3-fluorophenyl)oxirane

1-(3-fluorophenyl)ethane-1,2-diol

Refernces

• 1、 Guo, Zheng,Xie, Jinglei,Hu, Tao,Chen, Yunrong,Tao, Houchao,Yang, Xiaoyu. "Kinetic resolution ofN-aryl β-amino alcoholsviaasymmetric aminations of anilines". supporting information. p. 9394 - 9397. Retrieved 2021/09/22.
• 2、 -. "OXYSTEROLS AND METHODS OF USE THEREOF". Paragraph 00572. . Retrieved 2018/05/16.