2'-Deoxyguanosine 3',5'-Dibutanoate

Base Information

• Chemical Name: 2'-Deoxyguanosine 3',5'-Dibutanoate
• CAS No.: 79971-08-7
• Molecular Formula: C18H25N5O6
• Molecular Weight: 407.426
• Mol file: 79971-08-7.mol

Synonyms:2'-deoxyguanosine 3',5'-dibutyrate;2-deoxygalactose;(3S,4R,5S)-3,4,5,6-tetrakis(oxidanyl)hexanal;2-deoxyguanosine;2-Deoxy-L-glucose;3',5'-O-dibutyryl 2'-deoxyguanosine;8-aza-7-deaza-2'-deoxyguanosine;

Chemical Property of 2'-Deoxyguanosine 3',5'-Dibutanoate

Chemical Property:

• Melting Point: >250°C (dec.)
• Boiling Point: 640.7oC at 760 mmHg
• Flash Point: 341.3oC
• PSA: 152.41000
• Density: 1.52g/cm3
• LogP: 1.38690
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

2''-Deoxyguanosine3’,5’-Dibutanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2'-Deoxyguanosine 3’,5’-Dibutanoate is an intermediate in the synthesis of DNA adducts of Aflatoxin B1 (A357460). 2''-Deoxyguanosine 3’,5’-Dibutanoate is an intermediate in the synthesis of DNA adducts of Aflatoxin B1 (A357460).

Technology Process of 2'-Deoxyguanosine 3',5'-Dibutanoate

There total 1 articles about 2'-Deoxyguanosine 3',5'-Dibutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

butanoic acid anhydride (106-31-0) + 2'-Deoxyguanosine (961-07-9) → 3',5'-O-dibutyryl 2'-deoxyguanosine (79971-08-7)

Guidance literature:

With pyridine; In N,N-dimethyl acetamide; at 40 ℃; for 15h;

DOI:10.1021/ja00366a029

Reference yield: 90.0%

2-(4-nitrophenyl)ethanol (100-27-6) + 3',5'-O-dibutyryl 2'-deoxyguanosine (79971-08-7) → Butyric acid (2R,3S,5R)-5-{2-amino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-2-butyryloxymethyl-tetrahydro-furan-3-yl ester (288101-58-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; at 95 ℃; for 1h;

DOI:10.1016/S0040-4039(00)00461-5

Reference yield: 14.0%

aflatoxin B1 (1162-65-8) + 3',5'-O-dibutyryl 2'-deoxyguanosine (79971-08-7) → alfatoxin B2a (17878-54-5) + 050668-79-6 (50668-79-6) + <6aS-(6aα,8bβ,9α,9aα)>-8-(2-amino-1,6-dihydro-6-oxo-7H-purin-7-yl)-2,3-6a,8,9,9a-hexahydro-9-hydroxy-4-methoxycyclopentafuro<3',2':4,5>furo<2,3-h><1>benzopyran-1,11-dione (63425-04-7)

Guidance literature:

With benzil; In 1,2-dichloro-benzene; at 100 ℃; for 1h; Irradiation;

DOI:10.1021/ja00366a029

upstream raw materials:

butanoic acid anhydride

2'-Deoxyguanosine

Downstream raw materials:

alfatoxin B_2a

050668-79-6

<6aS-(6aα,8bβ,9α,9aα)>-8-(2-amino-1,6-dihydro-6-oxo-7H-purin-7-yl)-2,3-6a,8,9,9a-hexahydro-9-hydroxy-4-methoxycyclopentafuro<3',2':4,5>furo<2,3-h><1>benzopyran-1,11-dione

Butyric acid (2R,3S,5R)-5-{2-amino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-2-butyryloxymethyl-tetrahydro-furan-3-yl ester

Refernces