Guanosine, 2'-deoxy-6-O-[4-oxo-4-(3-pyridinyl)butyl]-

Base Information

• Chemical Name: Guanosine, 2'-deoxy-6-O-[4-oxo-4-(3-pyridinyl)butyl]-
• CAS No.: 189241-37-0
• Molecular Formula: C₁₉H₂₂N₆O₅
• Molecular Weight: 414.421
• Mol file: 189241-37-0.mol

Synonyms:2'-deoxy-O6-[4-oxo-4-(3-pyridyl)butyl]guanosine;

Chemical Property of Guanosine, 2'-deoxy-6-O-[4-oxo-4-(3-pyridinyl)butyl]-

Chemical Property:

• Boiling Point: 808.5±75.0 °C(Predicted)
• PSA: 158.50000
• Density: 1.62±0.1 g/cm3(Predicted)
• LogP: 1.06730

Purity/Quality:

97% ^*data from raw suppliers

O6-[1-oxo-1-(3-pyridyl)but-4-yl]-2''deoxyguanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: O6-[1-oxo-1-(3-pyridyl)but-4-yl]-2''deoxyguanosine is a alkylguanine-DNA alkyltransferase substrate adduct.

Technology Process of Guanosine, 2'-deoxy-6-O-[4-oxo-4-(3-pyridinyl)butyl]-

There total 4 articles about Guanosine, 2'-deoxy-6-O-[4-oxo-4-(3-pyridinyl)butyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2'-deoxy-O6-[3-[2-(3-pyridyl)-1,3-dithian-2-yl]propyl]guanosine (189241-39-2) → O6-[1-oxo-1-(3-pyridyl)but-4-yl]-2'deoxyguanosine (189241-37-0)

Guidance literature:

With N-chloro-succinimide; sodium carbonate; sodium sulfite; silver nitrate; In dichloromethane; acetonitrile; at 25 ℃; for 0.333333h;

DOI:10.1021/tx9602067

Reference yield:

2'-deoxy-N2-isobutyrylguanosine 3',5'-diisobutyrate (82921-42-4) → O6-[1-oxo-1-(3-pyridyl)but-4-yl]-2'deoxyguanosine (189241-37-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / triphenylphosphine; diethyl azodicarboxylate / dioxane / 18 h / 20 °C

2: 85 percent / NaOH / methanol / 3 h / 20 °C

3: 90 percent / N-chlorosuccinimide; Na₂SO₃; Na₂CO₃ / AgNO₃ / acetonitrile; CH₂Cl₂ / 0.33 h / 25 °C

With sodium hydroxide; N-chloro-succinimide; sodium carbonate; triphenylphosphine; sodium sulfite; diethylazodicarboxylate; silver nitrate; In 1,4-dioxane; methanol; dichloromethane; acetonitrile;

DOI:10.1021/tx9602067

Reference yield:

4-(1,3-dithian-2-yl)-4-((3-pyridyl)butan-1-ol → O6-[1-oxo-1-(3-pyridyl)but-4-yl]-2'deoxyguanosine (189241-37-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / triphenylphosphine; diethyl azodicarboxylate / dioxane / 18 h / 20 °C

2: 85 percent / NaOH / methanol / 3 h / 20 °C

3: 90 percent / N-chlorosuccinimide; Na₂SO₃; Na₂CO₃ / AgNO₃ / acetonitrile; CH₂Cl₂ / 0.33 h / 25 °C

With sodium hydroxide; N-chloro-succinimide; sodium carbonate; triphenylphosphine; sodium sulfite; diethylazodicarboxylate; silver nitrate; In 1,4-dioxane; methanol; dichloromethane; acetonitrile;

DOI:10.1021/tx9602067

upstream raw materials:

2'-deoxy-O⁶-[3-[2-(3-pyridyl)-1,3-dithian-2-yl]propyl]guanosine

2'-deoxy-N²-isobutyrylguanosine 3',5'-diisobutyrate

2'-deoxy-N²-isobutyryl-O⁶-[3-[2-(3-pyridyl)-1,3-dithian-2-yl]propyl]guanosine 3',5'-diisobutyrate