Butanamide, 2-bromo-3,3-dimethyl-N-(triphenylmethyl)-

Base Information

• Chemical Name: Butanamide, 2-bromo-3,3-dimethyl-N-(triphenylmethyl)-
• CAS No.: 190260-61-8
• Molecular Formula: C25H26BrNO
• Molecular Weight: 436.392
• DSSTox Substance ID: DTXSID30458934
• Nikkaji Number: J1.586.793K
• Mol file: 190260-61-8.mol

Synonyms:Butanamide, 2-bromo-3,3-dimethyl-N-(triphenylmethyl)-;190260-61-8;DTXSID30458934;N-Trityl-2-bromo-3,3-dimethylbutyramide

Chemical Property of Butanamide, 2-bromo-3,3-dimethyl-N-(triphenylmethyl)-

Chemical Property:

• XLogP3: 6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 6
• Exact Mass: 435.11978
• Heavy Atom Count: 28
• Complexity: 448

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C(C(=O)NC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)Br

Technology Process of Butanamide, 2-bromo-3,3-dimethyl-N-(triphenylmethyl)-

There total 3 articles about Butanamide, 2-bromo-3,3-dimethyl-N-(triphenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.2%

2-bromo-3,3-dimethylbutanoyl chloride (29336-30-9,86512-66-5) + Triphenylmethylamin (5824-40-8) → N-triphenylmethyl-2-bromo-3,3-dimethylbutanamide (190260-61-8)

Guidance literature:

With sodium hydroxide; In 1,2-dichloro-ethane; at -5 - 20 ℃;

DOI:10.1002/jhet.5570380432

Reference yield:

3,3-dimethylbutanoic acid chloride (7065-46-5) → N-triphenylmethyl-2-bromo-3,3-dimethylbutanamide (190260-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂ / 1 h / Heating

2: 55.2 percent / 20 percent aq. NaOH / 1,2-dichloro-ethane / -5 - 20 °C

With sodium hydroxide; bromine; In 1,2-dichloro-ethane;

DOI:10.1002/jhet.5570380432

Reference yield:

tert-Butylacetic acid (1070-83-3) → N-triphenylmethyl-2-bromo-3,3-dimethylbutanamide (190260-61-8)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 1 h / Heating

2: Br₂ / CCl₄ / 3.5 h / Heating

3: CCl₄; CH₂Cl₂

With thionyl chloride; bromine; In tetrachloromethane; dichloromethane;

upstream raw materials:

2-bromo-3,3-dimethylbutanoyl chloride

Triphenylmethylamin

3,3-dimethylbutanoic acid chloride

tert-Butylacetic acid

Downstream raw materials:

1-triphenylmethyl-3-tert-butylaziridinone

pivalaldehyde