Geranylgeranyl transferase inhibitor-2147

Base Information

• Chemical Name: Geranylgeranyl transferase inhibitor-2147
• CAS No.: 191102-87-1
• Molecular Formula: C28H30N4O3
• Molecular Weight: 470.56
• Nikkaji Number: J1.081.284D
• ChEMBL ID: CHEMBL27518
• Mol file: 191102-87-1.mol

Synonyms:geranylgeranyl transferase inhibitor-2147;GGTI 2147;GGTI-2147;GGTI2147

Chemical Property of Geranylgeranyl transferase inhibitor-2147

Chemical Property:

• Sensitive.: Light Sensitive & Hygroscopic
• Solubility.: Soluble in DMSO
• XLogP3: 5.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 10
• Exact Mass: 470.23179083
• Heavy Atom Count: 35
• Complexity: 702

Purity/Quality:

99% ^*data from raw suppliers

GGTI-2147 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)CC(C(=O)OC)NC(=O)C1=C(C=C(C=C1)NCC2=CN=CN2)C3=CC=CC4=CC=CC=C43
• Isomeric SMILES: CC(C)C[C@@H](C(=O)OC)NC(=O)C1=C(C=C(C=C1)NCC2=CN=CN2)C3=CC=CC4=CC=CC=C43
• Uses: GGTI-2147 is an inhibitors of protein geranylgeranyltransferase-I and protein prenylation. Increases prelamin A accumulation by inhibiting ZMPSTE24 protein in human fibroblast and increases cytosolic accumulation of Rac1 and elicites significant inhibition of GSIS from INS 832/13 cells.