Boc-(R)-2-(aMinoMethyl)-3-Methylbutanoic acid

Base Information

Chemical Name:Boc-(R)-2-(aMinoMethyl)-3-Methylbutanoic acid
CAS No.:191664-14-9
Molecular Formula:C11H21NO4
Molecular Weight:231.28900
Hs Code.:2924199090
Mol file:191664-14-9.mol

Synonyms:(2R)-2-([(TERT-BUTOXYCARBONYL)AMINO]METHYL)-3-METHYLBUTYRIC ACID;(2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutyric acid;(2R)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoic acid;Boc-(R)-2-(aMinoMethyl)-3-Methylbutanoic acid;(R)-2-(((tert-Butoxycarbonyl)amino)methyl)-3-methylbutanoic acid;

Suppliers and Price of Boc-(R)-2-(aMinoMethyl)-3-Methylbutanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoicAcid
50mg
$ 90.00

SynQuest Laboratories
(2R)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoic acid
250 mg
$ 648.00

SynQuest Laboratories
(2R)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoic acid
100 mg
$ 472.00

Oakwood
(R)-2-(((tert-Butoxycarbonyl)amino)methyl)-3-methylbutanoic acid
100mg
$ 315.00

Oakwood
(R)-2-(((tert-Butoxycarbonyl)amino)methyl)-3-methylbutanoic acid
250mg
$ 635.00

Matrix Scientific
(2R)-2-{[(tert-Butoxycarbonyl)amino]-methyl}-3-methylbutanoic acid 97%
250mg
$ 615.00

Crysdot
(R)-2-(((tert-Butoxycarbonyl)amino)methyl)-3-methylbutanoicacid 97%
250mg
$ 187.00

Crysdot
(R)-2-(((tert-Butoxycarbonyl)amino)methyl)-3-methylbutanoicacid 97%
1g
$ 475.00

Chem-Impex
Boc-(R)-2-(aminomethyl)-3-methylbutanoicacid
100MG
$ 541.63

Chemenu
(R)-2-(((tert-Butoxycarbonyl)amino)methyl)-3-methylbutanoicacid 97%
1g
$ 1197.00

Total 19 raw suppliers

Chemical Property of Boc-(R)-2-(aMinoMethyl)-3-Methylbutanoic acid

Chemical Property:

Boiling Point:360.4±25.0 °C(Predicted)
PKA:4.48±0.11(Predicted)
PSA：75.63000
Density:1.061±0.06 g/cm3(Predicted)
LogP:2.25880
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(2S)-2-{[(tert-Butoxycarbonyl)amino]methyl}-3-methylbutanoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Boc-(R)-2-(aMinoMethyl)-3-Methylbutanoic acid

There total 4 articles about Boc-(R)-2-(aMinoMethyl)-3-Methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 210345-86-1
(2R)-([amino]methyl)-3-methylbutanoic acid

: 191664-14-9
(R)-2-(((tert-butoxycarbonyl)amino)methyl)-3-methylbutanoic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; for 16h;
DOI:10.1002/hlca.19980810513

Reference yield:

: 145589-03-3,104266-90-2
(S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one

: 191664-14-9
(R)-2-(((tert-butoxycarbonyl)amino)methyl)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / TiCl₄, Et₃N / CH₂Cl₂ / 60 h / 0 °C

2: 77 percent / H₂O₂, LiOH*H₂O / H₂O; tetrahydrofuran / 1 h / 0 °C

3: 75 percent / aq. HCl / acetic acid / 48 h / Heating

4: 87 percent / aq. NaOH / dioxane / 16 h

With hydrogenchloride; lithium hydroxide; sodium hydroxide; dihydrogen peroxide; titanium tetrachloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetic acid;
DOI:10.1002/hlca.19980810513

Reference yield:

: 191664-12-7
N-[(R)-2-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-3-methyl-butyl]-benzamide

: 191664-14-9
(R)-2-(((tert-butoxycarbonyl)amino)methyl)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / H₂O₂, LiOH*H₂O / H₂O; tetrahydrofuran / 1 h / 0 °C

2: 75 percent / aq. HCl / acetic acid / 48 h / Heating

3: 87 percent / aq. NaOH / dioxane / 16 h

With hydrogenchloride; lithium hydroxide; sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; 1,4-dioxane; water; acetic acid;
DOI:10.1002/hlca.19980810513