2-Amino-3,4,5-trimethoxybenzamide

Base Information

Chemical Name:2-Amino-3,4,5-trimethoxybenzamide
CAS No.:19178-35-9
Molecular Formula:C10H14N2O4
Molecular Weight:226.232
Hs Code.:
DSSTox Substance ID:DTXSID00488309
Wikidata:Q82330889
Mol file:19178-35-9.mol

Synonyms:2-Amino-3,4,5-trimethoxybenzamide;19178-35-9;DTXSID00488309

Suppliers and Price of 2-Amino-3,4,5-trimethoxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Amino-3,4,5-trimethoxybenzamide

Chemical Property:

XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:226.09535693
Heavy Atom Count:16
Complexity:249

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C(=C(C(=C1)C(=O)N)N)OC)OC

Technology Process of 2-Amino-3,4,5-trimethoxybenzamide

There total 6 articles about 2-Amino-3,4,5-trimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.8%

: 61948-85-4
3,4,5-trimethoxyanthranilic acid

: 19178-35-9
2-amino-3,4,5-trimethoxybenzamide

Guidance literature:: 3,4,5-trimethoxyanthranilic acid; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 3.5h;

With ammonia; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 1916-07-0
3,4,5-trimethoxybenzoic acid methyl ester

: 19178-35-9
2-amino-3,4,5-trimethoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: HNO₃ / acetic anhydride / -5 - 0 °C

2: H₂ / Raney-Ni / acetic acid

3: N₂H₄*H₂O / propan-2-ol / Heating

4: Raney-Ni / propan-2-ol / Heating

With hydrogen; nitric acid; nickel; hydrazine hydrate; nickel; In acetic anhydride; acetic acid; isopropyl alcohol;
DOI:10.1007/BF00899833

Reference yield:

: 5081-42-5
3,4,5-trimethoxy-2-nitrobenzoic acid methyl ester

: 19178-35-9
2-amino-3,4,5-trimethoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Raney-Ni / acetic acid

2: N₂H₄*H₂O / propan-2-ol / Heating

3: Raney-Ni / propan-2-ol / Heating

With hydrogen; nickel; hydrazine hydrate; nickel; In acetic acid; isopropyl alcohol;
DOI:10.1007/BF00899833