1,3-Benzenedicarboxylic acid, 5-[[(1,2,3,4-tetrahydro-3-isoquinolinyl)carbonyl]amino]-, bis(phenylmethyl) ester

Base Information

Chemical Name:1,3-Benzenedicarboxylic acid, 5-[[(1,2,3,4-tetrahydro-3-isoquinolinyl)carbonyl]amino]-, bis(phenylmethyl) ester
CAS No.:192133-89-4
Molecular Formula:C32H28N2O5
Molecular Weight:520.585
Hs Code.:

Synonyms:

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Chemical Property of 1,3-Benzenedicarboxylic acid, 5-[[(1,2,3,4-tetrahydro-3-isoquinolinyl)carbonyl]amino]-, bis(phenylmethyl) ester

Chemical Property:

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Technology Process of 1,3-Benzenedicarboxylic acid, 5-[[(1,2,3,4-tetrahydro-3-isoquinolinyl)carbonyl]amino]-, bis(phenylmethyl) ester

There total 2 articles about 1,3-Benzenedicarboxylic acid, 5-[[(1,2,3,4-tetrahydro-3-isoquinolinyl)carbonyl]amino]-, bis(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 494847-53-9
5-[(2-tert-Butoxycarbonyl-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-isophthalic acid dibenzyl ester

: 192133-89-4
3-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With trifluoroacetic acid;
DOI:10.1016/S0960-894X(97)00211-4

Reference yield:

: 151838-62-9
N-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

: 192133-89-4
3-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylethylamine; bromotris(pyrrolidine)phosphonium hexafluorophosphate; DMAP / CH₂Cl₂ / 19 h / 20 °C

2: 86 mg / trifluoroacetic acid / 1 h / 20 °C

With dmap; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0223-5234(02)01351-X

Reference yield:

: 192133-89-4
3-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-1,2,3,4-tetrahydroisoquinoline

: 5-[(2-{6-[(Adamantan-1-ylmethyl)-carbamoyl]-3H-benzoimidazole-5-carbonyl}-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-isophthalic acid

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 3 h / Heating

2: 60 mg / bromotris(pyrrolidine)phosphonium hexafluorophosphate; diisopropylethylamine; DMAP / CH₂Cl₂ / 24 h / 20 °C

3: 98 percent / H₂ / Pd/C / tetrahydrofuran; methanol / 12 h

With dmap; hydrogen; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0223-5234(02)01351-X