1,3-Benzenedicarboxylic acid, 5-[[[3-[(6-carboxy-1H-benzimidazol-5-yl)carbonyl]-2,3,4,5-tetrahydro-1H -3-benzazepin-2-yl]carbonyl]amino]-, 1,3-bis(phenylmethyl) ester

Base Information

Chemical Name:1,3-Benzenedicarboxylic acid, 5-[[[3-[(6-carboxy-1H-benzimidazol-5-yl)carbonyl]-2,3,4,5-tetrahydro-1H -3-benzazepin-2-yl]carbonyl]amino]-, 1,3-bis(phenylmethyl) ester
CAS No.:192133-94-1
Molecular Formula:C42H34N4O8
Molecular Weight:722.754
Hs Code.:

1,3-Benzenedicarboxylic acid,
5-[[[3-[(6-carboxy-1H-benzimidazol-5-yl)carbonyl]-2,3,4,5-tetrahydro-1H
-3-benzazepin-2-yl]carbonyl]amino]-, 1,3-bis(phenylmethyl) ester

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Chemical Property of 1,3-Benzenedicarboxylic acid, 5-[[[3-[(6-carboxy-1H-benzimidazol-5-yl)carbonyl]-2,3,4,5-tetrahydro-1H -3-benzazepin-2-yl]carbonyl]amino]-, 1,3-bis(phenylmethyl) ester

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Technology Process of 1,3-Benzenedicarboxylic acid, 5-[[[3-[(6-carboxy-1H-benzimidazol-5-yl)carbonyl]-2,3,4,5-tetrahydro-1H -3-benzazepin-2-yl]carbonyl]amino]-, 1,3-bis(phenylmethyl) ester

There total 4 articles about 1,3-Benzenedicarboxylic acid, 5-[[[3-[(6-carboxy-1H-benzimidazol-5-yl)carbonyl]-2,3,4,5-tetrahydro-1H -3-benzazepin-2-yl]carbonyl]amino]-, 1,3-bis(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 188990-16-1
2,3,4,5-tetrahydro-1H-benzo[d]azepine-2-carboxylic acid hydrochloride

: 192133-94-1
5-{[3-(6-Carboxy-3H-benzoimidazole-5-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-2-carbonyl]-amino}-isophthalic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / Et₃N / H₂O; dioxane / 48 h / 20 °C

2: diisopropylethylamine; bromotris(pyrrolidine)phosphonium hexafluorophosphate; DMAP / CH₂Cl₂ / 19 h / 20 °C

3: 123 mg / trifluoroacetic acid / 1 h / 20 °C

4: acetonitrile / 3 h / Heating

With dmap; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; acetonitrile;
DOI:10.1016/S0223-5234(02)01351-X

Reference yield:

: 192133-86-1
N-(tert-butoxycarbonyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-2-carboxylic acid

: 192133-94-1
5-{[3-(6-Carboxy-3H-benzoimidazole-5-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-2-carbonyl]-amino}-isophthalic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diisopropylethylamine; bromotris(pyrrolidine)phosphonium hexafluorophosphate; DMAP / CH₂Cl₂ / 19 h / 20 °C

2: 123 mg / trifluoroacetic acid / 1 h / 20 °C

3: acetonitrile / 3 h / Heating

With dmap; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1016/S0223-5234(02)01351-X

Reference yield:

: 494847-54-0
5-[(3-tert-Butoxycarbonyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-2-carbonyl)-amino]-isophthalic acid dibenzyl ester

: 192133-94-1
5-{[3-(6-Carboxy-3H-benzoimidazole-5-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-2-carbonyl]-amino}-isophthalic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 123 mg / trifluoroacetic acid / 1 h / 20 °C

2: acetonitrile / 3 h / Heating

With trifluoroacetic acid; In acetonitrile;
DOI:10.1016/S0223-5234(02)01351-X