Benzenepropanal, a-chloro-

Base Information

• Chemical Name: Benzenepropanal, a-chloro-
• CAS No.: 19261-37-1
• Molecular Formula: C9H9ClO
• Molecular Weight: 168.623
• Mol file: 19261-37-1.mol

Synonyms:2-chloro-3-phenylpropanal oxime;2-chlorodihydrocinnamaldehyde;

Chemical Property of Benzenepropanal, a-chloro-

Chemical Property:

• Boiling Point: 104-106 °C(Press: 12 Torr)
• PSA: 17.07000
• Density: 1.176 g/cm3
• LogP: 2.03540

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanal, a-chloro-

There total 19 articles about Benzenepropanal, a-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-phenyl-propionaldehyde (104-53-0) → 2-chloro-3-phenyl-propionaldehyde (19261-37-1)

Guidance literature:

With N-chloro-succinimide; rac-Pro-OH; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1039/c6cc04639h

Reference yield: 89.0%

2-chloro-3-phenyl-2-(p-tolylsulfinyl)propanal → 2-chloro-3-phenyl-propionaldehyde (19261-37-1)

Guidance literature:

With ethylmagnesium bromide; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0040-4020(01)90408-9

Reference yield: 71.0%

(2E)-3-phenyl-2-propen-1-ol (4407-36-7) → 2-chloro-3-phenyl-propionaldehyde (19261-37-1)

Guidance literature:

With N-chloro-succinimide; [{Cp*IrCl₂}]₂; In tetrahydrofuran; water; at 20 ℃; for 23h;

DOI:10.1002/anie.201301013

upstream raw materials:

3-phenyl-propionaldehyde

benzene diazonium chloride

acrolein

2-(1-chloro-2-phenyl-ethyl)-4,4,6-trimethyl-5,6-dihydro-4H-[1,3]oxazine

Refernces

• 1、 Liu, Bin,Luo, Guoyong,Wang, Hongling,Hao, Lin,Yang, Song,Jin, Zhichao,Chi, Yonggui Robin. "Carbene-Catalyzed Direct Functionalization of the β-sp3-Carbon Atoms of α-Chloroaldehydes". . p. 12719 - 12723. Retrieved 2019.
• 2、 -. "COMPOUNDS AND USES THEREOF". Page/Page column 322; 323. . Retrieved 2020/10/20.
• 3、 West, Michael S.,Mills, L. Reginald,McDonald, Tyler R.,Lee, Jessica B.,Ensan, Deeba,Rousseaux, Sophie A. L.. "Synthesis of trans-2-Substituted Cyclopropylamines from α-Chloroaldehydes". supporting information. p. 8409 - 8413. Retrieved 2019/10/14.