3-Fluoro-4-formylbenzoic acid

Base Information

• Chemical Name: 3-Fluoro-4-formylbenzoic acid
• CAS No.: 193290-80-1
• Molecular Formula: C8H5FO3
• Molecular Weight: 168.124
• Hs Code.: 2916399090
• Mol file: 193290-80-1.mol

Synonyms:Benzoic acid,3-fluoro-4-formyl;

Chemical Property of 3-Fluoro-4-formylbenzoic acid

Chemical Property:

• Boiling Point: 330.6±27.0 °C(Predicted)
• PKA: 3.44±0.10(Predicted)
• PSA: 54.37000
• Density: 1.426±0.06 g/cm3(Predicted)
• LogP: 1.33640
• Storage Temp.: 2-8°C

Purity/Quality:

3-Fluoro-4-formylbenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Fluoro-4-formylbenzoic acid

There total 3 articles about 3-Fluoro-4-formylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-(dibromomethyl)-3-fluorobenzoic acid (777074-51-8) → 3-fluoro-4-formylbenzoic acid (193290-80-1)

Guidance literature:

With water; silver nitrate; In ethanol; at 50 ℃; for 0.916667h;

Reference yield:

methyl 3-fluoro-4-formylbenzoate (74733-25-8) → 3-fluoro-4-formylbenzoic acid (193290-80-1)

Guidance literature:

With lithium hydroxide; In acetonitrile; at 20 - 40 ℃; for 2h;

Reference yield:

3-fluoro-4-methyl-benzoic acid (350-28-7) → 3-fluoro-4-formylbenzoic acid (193290-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 40 h / 77 °C

2: silver nitrate / ethanol; water / 0.75 h / 50 °C

With N-Bromosuccinimide; silver nitrate; dibenzoyl peroxide; In tetrachloromethane; ethanol; water;

upstream raw materials:

4-(dibromomethyl)-3-fluorobenzoic acid

methyl 3-fluoro-4-formylbenzoate

3-fluoro-4-methyl-benzoic acid

Downstream raw materials:

methyl 3-fluoro-4-formylbenzoate

4-(2,5-cis/trans-dimethylpyrrolidine-1-carbonyl)-2-fluorobenzaldehyde

benzyl 3-fluoro-4-formylbenzoate

2-fluoro-terephthalic acid 4-methyl ester