4-(Dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide

Base Information

• Chemical Name: 4-(Dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide
• CAS No.: 193551-00-7
• Molecular Formula: C15H23N3O3
• Molecular Weight: 293.36100
• DSSTox Substance ID: DTXSID50274411
• Nikkaji Number: J1.216.501C
• Wikidata: Q82003772
• ChEMBL ID: CHEMBL46942
• Mol file: 193551-00-7.mol

Synonyms:193551-00-7;4-(Dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide;4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]benzamide;Benzamide, 4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-;CHEMBL46942;4-(dimethylamino)-N-(6-(hydroxyamino)-6-oxohexyl)benzamide;CAY10398;HDInhib_000016;SCHEMBL1232527;DTXSID50274411;RGWSSTALGUXZMU-UHFFFAOYSA-N;HMS3649O22;MD-85;BDBM50082666;MFCD05863979;CCG-208682;EC-000.2465;SR-01000946632;J-012531;SR-01000946632-1;4-Dimethylamino-N-(5-hydroxycarbamoyl-pentyl)-benzamide;4-Dimethylamino-N-(6-hydroxyamino-6-oxohexyl)benzamide;4-(Dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]benzenecarboxamide

Chemical Property of 4-(Dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide

Chemical Property:

• PSA: 81.67000
• LogP: 2.33000
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 293.17394160
• Heavy Atom Count: 21
• Complexity: 326

Purity/Quality:

99% ^*data from raw suppliers

CAY10398 ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=CC=C(C=C1)C(=O)NCCCCCC(=O)NO
• Description: CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 μM. Similar potency is observed with trapoxin A and B, whereas trichostatin A is more potent inhibitor of the enzyme. Trichostatin A also selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA. However, trichostatin A is much more expensive than CAY10398. CAY10398 thus represents a selective and cost-effective compound for the inhibition of HDAC.
• Uses: A histone deacetylase (HDAC1) inhibitor