(-)-5,11,17,23-tetrakis-tert-butyl-25,27-bis(diphenylphosphinooxy)-26-ethoxy-28-[(1R,2S,5R)menthyloxycarbonylmethoxy]calix[4]arene

Base Information

• Chemical Name: (-)-5,11,17,23-tetrakis-tert-butyl-25,27-bis(diphenylphosphinooxy)-26-ethoxy-28-[(1R,2S,5R)menthyloxycarbonylmethoxy]calix[4]arene
• CAS No.: 175671-53-1
• Molecular Formula: C₈₂H₉₈O₆P₂
• Molecular Weight: 1241.62
• Mol file: 175671-53-1.mol

Synonyms:

Chemical Property of (-)-5,11,17,23-tetrakis-tert-butyl-25,27-bis(diphenylphosphinooxy)-26-ethoxy-28-[(1R,2S,5R)menthyloxycarbonylmethoxy]calix[4]arene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-5,11,17,23-tetrakis-tert-butyl-25,27-bis(diphenylphosphinooxy)-26-ethoxy-28-[(1R,2S,5R)menthyloxycarbonylmethoxy]calix[4]arene

There total 2 articles about (-)-5,11,17,23-tetrakis-tert-butyl-25,27-bis(diphenylphosphinooxy)-26-ethoxy-28-[(1R,2S,5R)menthyloxycarbonylmethoxy]calix[4]arene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2S,5R)-menthol bromoacetate (16832-20-5,32815-12-6,55284-67-8) → (-)-5,11,17,23-tetrakis-tert-butyl-25,27-bis(diphenylphosphinooxy)-26-ethoxy-28-[(1R,2S,5R)menthyloxycarbonylmethoxy]calix[4]arene (175671-53-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) K₂CO₃ / 1.) acetonitrile, 2.) acetonitrile, reflux, 15 h

2: 1.) LiN(i-Pr)2 / 1.) THF, -78 deg, 2.) THF, -78 deg C

With potassium carbonate; lithium diisopropyl amide;

DOI:10.1039/c39930000604

Reference yield:

chloro-diphenylphosphine (1079-66-9,74391-44-9) + (-)-5,11,17,23-tetra-tert-butyl-25-ethoxy-26,28-dihydroxy-27-<(1R,2S,5R)menthyloxycarbonylmethoxy>calix<4>arene (175671-51-9) → (-)-5,11,17,23-tetrakis-tert-butyl-25,27-bis(diphenylphosphinooxy)-26-ethoxy-28-[(1R,2S,5R)menthyloxycarbonylmethoxy]calix[4]arene (175671-53-1)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 deg, 2.) THF, -78 deg C;

DOI:10.1039/c39930000604

upstream raw materials:

chloro-diphenylphosphine

(-)-5,11,17,23-tetra-tert-butyl-25-ethoxy-26,28-dihydroxy-27-<(1R,2S,5R)menthyloxycarbonylmethoxy>calix<4>arene

(1R,2S,5R)-menthol bromoacetate