3-Thiophenepropanoic acid, 5-(4-methylphenyl)-, ethyl ester

Base Information

• Chemical Name: 3-Thiophenepropanoic acid, 5-(4-methylphenyl)-, ethyl ester
• CAS No.: 194142-13-7
• Molecular Formula: C16H18O2S
• Molecular Weight: 274.384
• Mol file: 194142-13-7.mol

Synonyms:

Chemical Property of 3-Thiophenepropanoic acid, 5-(4-methylphenyl)-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Thiophenepropanoic acid, 5-(4-methylphenyl)-, ethyl ester

There total 4 articles about 3-Thiophenepropanoic acid, 5-(4-methylphenyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(5-p-tolyl-thiophen-3-ylmethyl)-malonic acid diethyl ester (649569-72-2) → 3-(5-p-tolyl-thiophen-3-yl)-propionic acid ethyl ester (194142-13-7)

Guidance literature:

With sodium chloride; In water; dimethyl sulfoxide; for 5h; Heating;

DOI:10.1016/j.bmc.2003.08.009

Reference yield:

Esonarimod (101973-77-7) → 3-(5-p-tolyl-thiophen-3-yl)-propionic acid ethyl ester (194142-13-7)

Guidance literature:

Multi-step reaction with 6 steps

1: H₂SO₄ / 5 h / Heating

2: DDQ / benzene / 1.5 h / 20 °C

3: LiAlH₄ / diethyl ether / 0.5 h / Heating

4: HMPA; thionyl chloride / tetrahydrofuran / 0.5 h / 20 °C

5: Na / ethanol / 1.5 h / Heating

6: NaCl / dimethylsulfoxide; H₂O / 5 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; sodium; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium chloride; In tetrahydrofuran; diethyl ether; ethanol; water; dimethyl sulfoxide; benzene;

DOI:10.1016/j.bmc.2003.08.009

Reference yield:

(5-p-tolyl-thiophen-3-yl)-methanol → 3-(5-p-tolyl-thiophen-3-yl)-propionic acid ethyl ester (194142-13-7)

Guidance literature:

Multi-step reaction with 3 steps

1: HMPA; thionyl chloride / tetrahydrofuran / 0.5 h / 20 °C

2: Na / ethanol / 1.5 h / Heating

3: NaCl / dimethylsulfoxide; H₂O / 5 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; thionyl chloride; sodium; sodium chloride; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;

DOI:10.1016/j.bmc.2003.08.009

upstream raw materials:

2-(5-p-tolyl-thiophen-3-ylmethyl)-malonic acid diethyl ester

Esonarimod

4-chloromethyl-2-p-tolyl-thiophene

Downstream raw materials:

3-(5-p-tolyl-thiophen-3-yl)-propionic acid

Refernces