1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-4-methyl-7-oxo-3-[( phenylmethyl)thio]-, (4-nitrophenyl)methyl ester, (4R,5S,6S)-

Base Information

• Chemical Name: 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-4-methyl-7-oxo-3-[( phenylmethyl)thio]-, (4-nitrophenyl)methyl ester, (4R,5S,6S)-
• CAS No.: 194983-50-1
• Molecular Formula: C30H38N2O6SSi
• Molecular Weight: 582.793
• Mol file: 194983-50-1.mol

Synonyms:

Chemical Property of 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-4-methyl-7-oxo-3-[( phenylmethyl)thio]-, (4-nitrophenyl)methyl ester, (4R,5S,6S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-4-methyl-7-oxo-3-[( phenylmethyl)thio]-, (4-nitrophenyl)methyl ester, (4R,5S,6S)-

There total 3 articles about 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-4-methyl-7-oxo-3-[( phenylmethyl)thio]-, (4-nitrophenyl)methyl ester, (4R,5S,6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

phenylmethanethiol (100-53-8) + (4R,5S,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(2-diethylcarbamoyl-benzenesulfinyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester (158168-62-8) → (4R,5S,6S)-3-Benzylsulfanyl-6-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester (194983-50-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; magnesium bromide; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1016/S0040-4039(97)01239-2

Reference yield:

(4R,5S,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(2-diethylcarbamoyl-phenylsulfanyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester (158168-59-3) → (4R,5S,6S)-3-Benzylsulfanyl-6-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester (194983-50-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / 1 N NaHCO₃, m-chloroperoxybenzoic acid / CH₂Cl₂ / 1 h / 0 °C

2: 79 percent / MgBr₂*Et₂O, iso-Pr₂NEt / tetrahydrofuran / 1 h

With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; magnesium bromide; In tetrahydrofuran; dichloromethane;

DOI:10.1248/cpb.46.893

Reference yield:

2-(4-nitrobenzyloxycarbonylamino)ethanethiol (65750-59-6) → (4R,5S,6S)-3-Benzylsulfanyl-6-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester (194983-50-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 14 percent / MgBr₂*Et₂O, i-Pr₂NEt / tetrahydrofuran / 1 h / Ambient temperature

2: 89 percent / m-CPBA

3: 79 percent / MgBr₂*Et₂O, i-Pr₂NEt / tetrahydrofuran / 1 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; magnesium bromide; In tetrahydrofuran;

DOI:10.1016/S0040-4039(97)01239-2

upstream raw materials:

phenylmethanethiol

(4R,5S,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(2-diethylcarbamoyl-benzenesulfinyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

(4R,5S,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(2-diethylcarbamoyl-phenylsulfanyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

2-(4-nitrobenzyloxycarbonylamino)ethanethiol