L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, phenylmethyl ester, monohydrochloride

Base Information

• Chemical Name: L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, phenylmethyl ester, monohydrochloride
• CAS No.: 19515-95-8
• Molecular Formula: C20H24Cl2N2O2.ClH
• Molecular Weight: 431.79
• Mol file: 19515-95-8.mol

Synonyms:

Chemical Property of L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, phenylmethyl ester, monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, phenylmethyl ester, monohydrochloride

There total 1 articles about L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, phenylmethyl ester, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

L-PAM (148-82-3,8057-25-8) + benzyl alcohol (100-51-6,185532-71-2) → melphalan benzyl ester hydrochloride salt (19515-95-8)

Guidance literature:

With hydrogenchloride; for 2h; Ambient temperature;

DOI:10.1021/jm00143a009

Reference yield: 82.0%

melphalan benzyl ester hydrochloride salt (19515-95-8) + Ac-Asn-Arg-Val-Tyr-Val-His-Pro (77414-01-8) → Ac-Asn-Arg-Val-Tyr-Val-His-Pro-Mel-OBzl (79145-89-4)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 60 ℃; for 7h;

DOI:10.1021/jm00143a009

Reference yield:

melphalan benzyl ester hydrochloride salt (19515-95-8) → Ac-Asn-Arg-Val-Tyr-Val-His-Pro-Mel (79145-91-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / hydroxybenzotriazole monohydrate, dicyclohexylcarbodiimide / dimethylformamide / 7 h / 60 °C

2: 51 percent / H₂ / 10percent Pd/C / dimethylformamide / 1.5 h / 760 Torr

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1021/jm00143a009

upstream raw materials:

L-PAM

benzyl alcohol

Downstream raw materials:

Ac-Asn-Arg-Val-Tyr-Val-His-Pro-Mel-OBzl

Ac-Asn-Arg-Val-Tyr-Val-His-Pro-Mel