1-IODOISOQUINOLINE

Base Information

• Chemical Name: 1-IODOISOQUINOLINE
• CAS No.: 19658-77-6
• Molecular Formula: C9H6IN
• Molecular Weight: 255.058
• Hs Code.: 2933499090
• Mol file: 19658-77-6.mol

Synonyms:1-iodoisoquiniline;1-iodo-isoquinoline;2-iodoisoquinoline;isoquinoline,1-iodo;1-iodoisoquinolone;iodoisoquinoline;1-Iodoisochinolin;

Chemical Property of 1-IODOISOQUINOLINE

Chemical Property:

• Vapor Pressure: 0.000214mmHg at 25°C
• Melting Point: 72-76℃
• Boiling Point: 336.8oC at 760 mmHg
• PKA: 2.27±0.30(Predicted)
• Flash Point: 157.5oC
• PSA: 12.89000
• Density: 1.837g/cm3
• LogP: 2.83940
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: soluble in Methanol

Purity/Quality:

97% ^*data from raw suppliers

1-Iodoisoquinoline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-IODOISOQUINOLINE

There total 11 articles about 1-IODOISOQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-hydroxyisoquinoline (491-30-5,87602-67-3) → 1-iodoisoquiniline (19658-77-6)

Guidance literature:

1-hydroxyisoquinoline; With pyridine; trifluoromethylsulfonic anhydride; In acetonitrile; at 20 - 40 ℃; for 2h;

With trifluorormethanesulfonic acid; sodium iodide; In acetonitrile; at 20 ℃; for 12.1667h;

With sodium hydroxide; In water; toluene; acetonitrile; at 5 ℃; pH=10;

DOI:10.1021/jo900726f

Reference yield: 96.0%

C9H6ClMgN*ClLi → 1-iodoisoquiniline (19658-77-6)

Guidance literature:

With iodine; In tetrahydrofuran; at -20 ℃; Product distribution / selectivity;

Reference yield: 93.0%

1-chloroisoquinoline (19493-44-8) → 1-iodoisoquiniline (19658-77-6)

Guidance literature:

1-chloroisoquinoline; With sodium iodide; In propiononitrile; at 20 ℃; Inert atmosphere;

With chloro-trimethyl-silane; In propiononitrile; for 15h; Reflux;

upstream raw materials:

1-chloroisoquinoline

isoquinoline

isoquinolin-1-yl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

1-(trifluoromethanesulfonyloxy)isoquinoline

Downstream raw materials:

isoquinoline

1,1'-Biisoquinoline

ethyl 2-(isoquinolin-1-yl)acetate

1-[2-(Diphenyl-phosphinoyl)-3,6-dimethoxy-phenyl]-isoquinoline