1,2,3,4,9,9a-Hexahydro-5,9,11,14-tetrahydroxy-9-methyl-4,10,12-trioxo-3,2,3a-[1]pentene[1,4,5]triyl-3aH-benz[f]indene-13-carboxamide

Base Information

• Chemical Name: 1,2,3,4,9,9a-Hexahydro-5,9,11,14-tetrahydroxy-9-methyl-4,10,12-trioxo-3,2,3a-[1]pentene[1,4,5]triyl-3aH-benz[f]indene-13-carboxamide
• CAS No.: 115747-16-5
• Molecular Formula: C20H17NO8
• Molecular Weight: 399.35
• Mol file: 115747-16-5.mol

Synonyms:

Chemical Property of 1,2,3,4,9,9a-Hexahydro-5,9,11,14-tetrahydroxy-9-methyl-4,10,12-trioxo-3,2,3a-[1]pentene[1,4,5]triyl-3aH-benz[f]indene-13-carboxamide

Chemical Property:

• PSA: 175.22000
• LogP: -0.07110

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4,9,9a-Hexahydro-5,9,11,14-tetrahydroxy-9-methyl-4,10,12-trioxo-3,2,3a-[1]pentene[1,4,5]triyl-3aH-benz[f]indene-13-carboxamide

There total 3 articles about 1,2,3,4,9,9a-Hexahydro-5,9,11,14-tetrahydroxy-9-methyl-4,10,12-trioxo-3,2,3a-[1]pentene[1,4,5]triyl-3aH-benz[f]indene-13-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

tetracycline hydrochloride (64-75-5,22024-49-3,23313-80-6,112453-36-8) → lumitetracycline (115747-16-5) + anhydrotetracycline

Guidance literature:

With phosphate buffer pH 6.4; In water; at 10 ℃; for 10h; Yields of byproduct given; Irradiation;

DOI:10.1021/jo00295a042

Reference yield: 50.0%

tetracycline (60-54-8) → lumitetracycline (115747-16-5)

Guidance literature:

With acetic acid; In acetonitrile; at 10 ℃; for 13h; Irradiation;

DOI:10.1021/jo00295a042

Reference yield:

4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide (7005-26-7) → Lumitetracycline (115747-16-5)

Guidance literature:

With benzophenone; 1,1-Diphenylmethanol; for 3h; Quantum yield; Ambient temperature; Irradiation; pH 6.0;

DOI:10.1021/jo00016a030

upstream raw materials:

tetracycline

tetracycline hydrochloride

4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide