N-(4-methylphenyl)furan-2-carboxamide

Base Information

• Chemical Name: N-(4-methylphenyl)furan-2-carboxamide
• CAS No.: 1982-62-3
• Molecular Formula: C12H11NO2
• Molecular Weight: 201.225
• DSSTox Substance ID: DTXSID40354857
• Nikkaji Number: J1.855.875K
• Wikidata: Q82133330
• ChEMBL ID: CHEMBL1214571
• Mol file: 1982-62-3.mol

Synonyms:N-(4-methylphenyl)furan-2-carboxamide;N-(p-tolyl)furan-2-carboxamide;N-(4-methylphenyl)-2-furamide;1982-62-3;Furan-2-carboxylic acid p-tolylamide;Cambridge id 5128154;Oprea1_323842;Oprea1_685418;CBDivE_005261;MLS001210335;SCHEMBL1846669;CHEMBL1214571;DTXSID40354857;STK249527;AKOS000733173;SMR000504853;CS-0328392;Z28134713

Chemical Property of N-(4-methylphenyl)furan-2-carboxamide

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 201.078978594
• Heavy Atom Count: 15
• Complexity: 222

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NC(=O)C2=CC=CO2

Technology Process of N-(4-methylphenyl)furan-2-carboxamide

There total 9 articles about N-(4-methylphenyl)furan-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

p-toluidine (106-49-0,12221-03-3) + 2-furoyl-1H-1,2,3-benzotriazole (144223-33-6) → N-(p-tolyl)furan-2-carboxamide (1982-62-3)

Guidance literature:

In chloroform; at 80 ℃; for 0.166667h; microwave irradiation;

DOI:10.1021/jo052443x

Reference yield: 91.0%

N-methyl-N-phenylfuran-2-carboxamide (67735-51-7) + p-toluidine (106-49-0,12221-03-3) → N-(p-tolyl)furan-2-carboxamide (1982-62-3)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at 23 ℃; for 15h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/jacs.9b04136

Reference yield: 81.0%

2-furancarbonitrile (617-90-3) + bis(4-methylphenyl)iodonium trifluoromethanesulfonate (123726-16-9) → N-(p-tolyl)furan-2-carboxamide (1982-62-3)

Guidance literature:

With copper diacetate; In water; 1,2-dichloro-ethane; at 80 ℃; for 20h; Schlenk technique; Sealed tube;

upstream raw materials:

2-furancarbonyl chloride

p-toluidine

2-furoyl-1H-1,2,3-benzotriazole

2-furanoic acid

Downstream raw materials:

N-[(1H-1,2,3-benzotriazol-1-yl)(2-furyl)methylidene]-4-methylaniline

N-benzyl-N′-(p-tolyl)furan-2-carboximidamide

N-p-tolyl-furan-2-carboximidoyl chloride

C₂₂H₁₉NO₄