1H-Indole-6-carboxylic acid, 3-[1-(1,3-benzodioxol-5-yl)-2-[[[4-(1-methylethyl)phenyl]sulfonyl]amino]-2 -oxoethyl]-1-ethyl-

Base Information

• Chemical Name: 1H-Indole-6-carboxylic acid, 3-[1-(1,3-benzodioxol-5-yl)-2-[[[4-(1-methylethyl)phenyl]sulfonyl]amino]-2 -oxoethyl]-1-ethyl-
• CAS No.: 199589-29-2
• Molecular Formula: C₂₉H₂₈N₂O₇S
• Molecular Weight: 548.617
• Mol file: 199589-29-2.mol

Synonyms:

Chemical Property of 1H-Indole-6-carboxylic acid, 3-[1-(1,3-benzodioxol-5-yl)-2-[[[4-(1-methylethyl)phenyl]sulfonyl]amino]-2 -oxoethyl]-1-ethyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole-6-carboxylic acid, 3-[1-(1,3-benzodioxol-5-yl)-2-[[[4-(1-methylethyl)phenyl]sulfonyl]amino]-2 -oxoethyl]-1-ethyl-

There total 7 articles about 1H-Indole-6-carboxylic acid, 3-[1-(1,3-benzodioxol-5-yl)-2-[[[4-(1-methylethyl)phenyl]sulfonyl]amino]-2 -oxoethyl]-1-ethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[1-benzo[1,3]dioxol-5-yl-2-(4-isopropyl-benzenesulfonylamino)-2-oxo-ethyl]-1-ethyl-1H-indole-6-carboxylic acid methyl ester (199589-28-1) → 3-[1-benzo[1,3]dioxol-5-yl-2-(4-isopropyl-benzenesulfonylamino)-2-oxo-ethyl]-1-ethyl-1H-indole-6-carboxylic acid (199589-29-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; for 6h; Heating;

DOI:10.1016/S0960-894X(01)00660-6

Reference yield:

4-isopropylbenzenesulfonamide (6335-39-3) → 3-[1-benzo[1,3]dioxol-5-yl-2-(4-isopropyl-benzenesulfonylamino)-2-oxo-ethyl]-1-ethyl-1H-indole-6-carboxylic acid (199589-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 12 h / Heating

2: NaOH / tetrahydrofuran; methanol / 6 h / Heating

With sodium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/S0960-894X(01)00660-6

Reference yield:

6-bromo-1-ethyl-1H-indole (199589-20-3) → 3-[1-benzo[1,3]dioxol-5-yl-2-(4-isopropyl-benzenesulfonylamino)-2-oxo-ethyl]-1-ethyl-1H-indole-6-carboxylic acid (199589-29-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sBuLi / diethyl ether / -78 °C

1.2: diethyl ether / -78 - -20 °C

2.1: 2,6-dimethylpyridine / dimethylformamide / 8 h / 80 °C

3.1: NaOH / methanol; dioxane / 1 h / Heating

4.1: CH₂Cl₂ / 12 h / Heating

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 12 h / Heating

6.1: NaOH / tetrahydrofuran; methanol / 6 h / Heating

With 2,6-dimethylpyridine; sodium hydroxide; sec.-butyllithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00660-6

upstream raw materials:

3-[1-benzo[1,3]dioxol-5-yl-2-(4-isopropyl-benzenesulfonylamino)-2-oxo-ethyl]-1-ethyl-1H-indole-6-carboxylic acid methyl ester

4-isopropylbenzenesulfonamide

6-bromo-1-ethyl-1H-indole

methyl 1-ethylindole-6-carboxylate