ethyl 5-fluoro-3-formyl-1H-indole-2-carboxylate

Base Information

• Chemical Name: ethyl 5-fluoro-3-formyl-1H-indole-2-carboxylate
• CAS No.: 199603-85-5
• Molecular Formula: C12H10FNO3
• Molecular Weight: 235.215
• DSSTox Substance ID: DTXSID20402269
• Nikkaji Number: J902.016K
• Wikidata: Q82205655

Synonyms:ethyl 5-fluoro-3-formyl-1H-indole-2-carboxylate;199603-85-5;5-fluoro-3-formyl-1H-indole-2-carboxylic acid ethyl ester;Oprea1_036974;SCHEMBL3275793;DTXSID20402269;IETRZXCTCCBKSO-UHFFFAOYSA-N;BBL020539;MFCD04966928;STK893228;AKOS001476064;BB 0249880;CS-0336576;ethyl5-fluoro-3-formyl-1H-indole-2-carboxylate;Z3214214387;3-Formyl-5-fluoro-1H-indole-2-carboxylic acid ethyl ester;5-Fluoro-3-formyl-1H-indole-2-carboxylic acid ethyl ester

Chemical Property of ethyl 5-fluoro-3-formyl-1H-indole-2-carboxylate

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 235.06447134
• Heavy Atom Count: 17
• Complexity: 310

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=C(C2=C(N1)C=CC(=C2)F)C=O

Technology Process of ethyl 5-fluoro-3-formyl-1H-indole-2-carboxylate

There total 2 articles about ethyl 5-fluoro-3-formyl-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 5-fluoro-1H-indole-2-carboxylate (348-36-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → ethyl 5-fluoro-3-formyl-1H-indole-2-carboxylate (199603-85-5)

Guidance literature:

With trichlorophosphate; at 80 - 100 ℃; for 2h;

DOI:10.1002/ardp.200700161

Reference yield:

ethyl 5-fluoro-1H-indole-2-carboxylate (348-36-7) + N-methyl-N-phenylformamide (93-61-8) → ethyl 5-fluoro-3-formyl-1H-indole-2-carboxylate (199603-85-5)

Guidance literature:

With sodium acetate; trichlorophosphate; Yield given. Multistep reaction;

DOI:10.1002/jhet.5570340510

Reference yield: 90.0%

2,4-Dichloroaniline (554-00-7,51908-09-9) + ethyl 5-fluoro-3-formyl-1H-indole-2-carboxylate (199603-85-5) → C18H13Cl2FN2O2 (1040379-53-0)

Guidance literature:

With acetic acid; In methanol; for 0.0833333h; Microwave irradiation;

DOI:10.1002/ardp.200700161

upstream raw materials:

ethyl 5-fluoro-1H-indole-2-carboxylate

N-methyl-N-phenylformamide

N,N-dimethyl-formamide

Downstream raw materials:

C₁₈H₁₃Cl₂FN₂O₂

C₁₉H₁₇FN₂O₂

C₁₈H₁₄FN₃O₄

C₁₈H₁₅FN₂O₂

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 199603-85-5 1H-Indole-2-carboxylic acid, 5-fluoro-3-formyl-, ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send