(R)-2-Hydroxybutanoic acid

Base Information

• Chemical Name: (R)-2-Hydroxybutanoic acid
• CAS No.: 20016-85-7
• Molecular Formula: C4H8O3
• Molecular Weight: 104.106
• Hs Code.: 2918199090
• European Community (EC) Number: 627-239-9
• UNII: UC8XN5ZT94
• DSSTox Substance ID: DTXSID501311184
• Nikkaji Number: J57.684K
• Wikidata: Q27122144
• Metabolomics Workbench ID: 57474
• Mol file: 20016-85-7.mol

Synonyms:(R)-2-Hydroxybutanoic acid;20016-85-7;(R)-2-Hydroxybutyric acid;(2R)-2-hydroxybutanoic acid;Butanoic acid, 2-hydroxy-, (2R)-;D-2-hydroxybutyric acid;2-Hydroxybutyric acid, (-)-;d-2-hydroxybutanoic acid;UNII-UC8XN5ZT94;UC8XN5ZT94;(-)-alpha-Hydroxybutyric acid;(r)-hydroxybutyric acid;(R)--Hydroxybutyric acid;(R)-2-Hydroxybutanoicacid;bmse000361;(-)-2-hydroxybutyric acid;SCHEMBL264859;CHEBI:50612;DTXSID501311184;(R)-(+)-2-Hydroxybutanoic acid;LMFA01050455;MFCD01318570;AKOS006239594;(-)-.ALPHA.-HYDROXYBUTYRIC ACID;BS-15885;CS-0107851;(R)-2-Hydroxybutyric acid, >=97.0% (T);EN300-34916;J-012945;Q27122144

Chemical Property of (R)-2-Hydroxybutanoic acid

Chemical Property:

• Vapor Pressure: 0.000979mmHg at 25°C
• Melting Point: 50-54oC
• Boiling Point: 238.3oC at 760 mmHg
• PKA: 3.83±0.10(Predicted)
• Flash Point: 112.2oC
• PSA: 57.53000
• Density: 1.195g/cm3
• LogP: -0.15810
• Storage Temp.: 2-8°C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 104.047344113
• Heavy Atom Count: 7
• Complexity: 69.3

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-2-Hydroxybutanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCC(C(=O)O)O
• Isomeric SMILES: CC[C@H](C(=O)O)O
• Uses: (R)-2-Hydroxybutanoic Acid can be used as remedy for a hangover.

Technology Process of (R)-2-Hydroxybutanoic acid

There total 5 articles about (R)-2-Hydroxybutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-Hydroxy-N-methyl-butyramide (133964-75-7) → (R)-2-hydroxylbutanoic acid (20016-85-7) + (2S)-2-hydroxybutanoic acid (3347-90-8)

Guidance literature:

With sulfuric acid; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

DOI:10.1021/jo9722820

Reference yield:

(1S,2S,6R,7R)-4-(1-Methoxymethoxy-propyl)-1,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.02,6]dec-4-ene (89426-82-4) → (R)-2-hydroxylbutanoic acid (20016-85-7) + (2S)-2-hydroxybutanoic acid (3347-90-8)

Guidance literature:

With sulfuric acid; for 24h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

DOI:10.1016/S0040-4039(01)91142-6

Reference yield:

2-Hydroxybutanoic acid (600-15-7,565-70-8) → 2-Oxobutyric acid (600-18-0) + (R)-2-hydroxylbutanoic acid (20016-85-7)

Guidance literature:

With glycolate oxidase from Spinacia oleracea; oxygen; ethylenediamine; Flavin mononucleotide; In water; for 22h;

DOI:10.1021/jo971298n

upstream raw materials:

(1S,2S,6R,7R)-4-(1-Methoxymethoxy-propyl)-1,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-ene

(R)-2-Acetoxy-butyric acid (1R,2R)-2,3-dihydroxy-1-(hydroxy-diphenyl-methyl)-3,3-diphenyl-propyl ester

2-Hydroxybutanoic acid

(S)-2-Hydroxy-N-methyl-butyramide

Downstream raw materials:

N-benzyl (R)-2-hydroxylbutanamide

2-Oxobutyric acid

(R)-3,6-diethyl-1,4-dioxane-2,5-dione

L,L-dilactide