2-amino-2-methyl-N-phenylpropanamide

Base Information

• Chemical Name: 2-amino-2-methyl-N-phenylpropanamide
• CAS No.: 20049-03-0
• Molecular Formula: C10H14N2O
• Molecular Weight: 178.234
• European Community (EC) Number: 894-830-8
• Mol file: 20049-03-0.mol

Synonyms:2-amino-2-methyl-N-phenylpropanamide;20049-03-0;2-methyl-N~1~-phenylalaninamide hydrochloride;Propanamide, 2-amino-2-methyl-N-phenyl-;2-methyl-N-phenylalaninamide;SCHEMBL2745516;MFCD11580873;AKOS010515381;EN300-72653

Chemical Property of 2-amino-2-methyl-N-phenylpropanamide

Chemical Property:

• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 178.110613074
• Heavy Atom Count: 13
• Complexity: 183

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C(=O)NC1=CC=CC=C1)N

Technology Process of 2-amino-2-methyl-N-phenylpropanamide

There total 4 articles about 2-amino-2-methyl-N-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-bromo-2-methyl-N-phenylpropanamide (2322-45-4) → 2-amino-2-methyl-N-phenyl-propanamide (20049-03-0)

Guidance literature:

With potassium phosphate; copper(I) bromide dimethylsulfide complex; ammonium bromide; triphenylphosphine; In toluene; at 25 ℃; for 23h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201706293

Reference yield:

aniline (62-53-3) → 2-amino-2-methyl-N-phenyl-propanamide (20049-03-0)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 25 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 25 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1002/jhet.4443

Reference yield:

→ 2-amino-2-methyl-N-phenyl-propanamide (20049-03-0)

Guidance literature:

entsprech. Diazolidin 3a, Hydrolyse;

DOI:10.1021/jo00423a013

upstream raw materials:

2-bromo-2-methyl-N-phenylpropanamide

aniline

tert-butyl (2-methyl-1-oxo-1-(phenylamino)propan-2-yl)carbamate