(4-Bromo-benzyloxy)-acetaldehyde

Base Information

• Chemical Name: (4-Bromo-benzyloxy)-acetaldehyde
• CAS No.: 201341-14-2
• Molecular Formula: C9H9BrO2
• Molecular Weight: 229.073
• DSSTox Substance ID: DTXSID40446483
• Nikkaji Number: J1.740.025H
• Wikidata: Q82265133
• Mol file: 201341-14-2.mol

Synonyms:(4-Bromo-benzyloxy)-acetaldehyde;201341-14-2;4-bromobenzyloxyacetaldehyde;SCHEMBL5004333;DTXSID40446483;SRMIJRWWQFMZCS-UHFFFAOYSA-N;AKOS021144782

Chemical Property of (4-Bromo-benzyloxy)-acetaldehyde

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 227.97859
• Heavy Atom Count: 12
• Complexity: 131

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1COCC=O)Br

Technology Process of (4-Bromo-benzyloxy)-acetaldehyde

There total 6 articles about (4-Bromo-benzyloxy)-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(4-bromobenzyloxy)ethanol (400837-92-5) → 2-((4-bromobenzyl)oxy)acetaldehyde (201341-14-2)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/ja012709r

Reference yield:

1-bromo-4-(2,2-diethoxy-ethoxymethyl)-benzene (787576-31-2) → 2-((4-bromobenzyl)oxy)acetaldehyde (201341-14-2)

Guidance literature:

With hydrogenchloride; In diethyl ether; water; at 20 ℃; for 16h;

Reference yield:

3-((4-bromobenzyl)oxy)propane-1,2-diol → 2-((4-bromobenzyl)oxy)acetaldehyde (201341-14-2)

Guidance literature:

With sodium periodate; In tetrahydrofuran; water; at 0 - 20 ℃; for 4h;

DOI:10.1021/acs.orglett.9b01511

upstream raw materials:

2-(4-bromobenzyloxy)ethanol

1-bromomethyl-4-bromobenzene

1-bromo-4-(2,2-diethoxy-ethoxymethyl)-benzene

Downstream raw materials:

(S)-2-(4-Bromo-benzyloxymethyl)-2,3-dihydro-pyran-4-one

((1R,2R)-2-Methoxymethoxy-1-vinyl-tetradecyloxy)-acetic acid (2S,4S)-2-(4-bromo-benzyloxymethyl)-3,4-dihydro-2H-pyran-4-yl ester

[(1S,2S)-1-(4-Bromo-benzyloxymethyl)-2-methyl-but-3-enyl]-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amine

Refernces

• 1、 Chen, Pan-Pan,Hong, Xin,Jarvo, Elizabeth R.,McGinnis, Tristan M.,Sanford, Amberly B.,Thane, Taylor A.. "Nickel-Catalyzed Alkyl-Alkyl Cross-Electrophile Coupling Reaction of 1,3-Dimesylates for the Synthesis of Alkylcyclopropanes". supporting information. . Retrieved 2020/03/23.
• 2、 -. "ISOQUINOLINE-5-SULFONIC ACID AMIDES AS INHIBITORS OF AKT (PROTEIN KINASE B)". Page 44. . Retrieved 2010/02/09.