2-Butanone, 1-[(2S,4S,6R,8R,10S)-10-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-meth oxy-8-[[(4-methoxyphenyl)methoxy]methyl]-1,7-dioxaspiro[5.5]undec-2-yl ]-

Base Information

Chemical Name:2-Butanone, 1-[(2S,4S,6R,8R,10S)-10-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-meth oxy-8-[[(4-methoxyphenyl)methoxy]methyl]-1,7-dioxaspiro[5.5]undec-2-yl ]-
CAS No.:201354-99-6
Molecular Formula:C29H48O7Si
Molecular Weight:536.781
Hs Code.:

2-Butanone,
1-[(2S,4S,6R,8R,10S)-10-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-meth
oxy-8-[[(4-methoxyphenyl)methoxy]methyl]-1,7-dioxaspiro[5.5]undec-2-yl
]-

Synonyms:

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Chemical Property of 2-Butanone, 1-[(2S,4S,6R,8R,10S)-10-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-meth oxy-8-[[(4-methoxyphenyl)methoxy]methyl]-1,7-dioxaspiro[5.5]undec-2-yl ]-

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Butanone, 1-[(2S,4S,6R,8R,10S)-10-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-meth oxy-8-[[(4-methoxyphenyl)methoxy]methyl]-1,7-dioxaspiro[5.5]undec-2-yl ]-

There total 60 articles about 2-Butanone, 1-[(2S,4S,6R,8R,10S)-10-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-meth oxy-8-[[(4-methoxyphenyl)methoxy]methyl]-1,7-dioxaspiro[5.5]undec-2-yl ]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 638222-34-1
(2R,4S,6R,8R,10S)-10-(tert-butyldimethylsilanyloxy)-2-(2-ethylprop-2-en-1-yl)-4-methoxy-8-(p-methoxybenzyloxymethyl)-1,7-dioxaspiro[5.5]undecane

: 201354-99-6
1-[(2S,4S,6R,8R,10S)-10-(tert-butyldimethylsilanyloxy)-4-methoxy-8-(p-methoxybenzyloxymethyl)-1,7-dioxaspiro[5.5]undec-2-yl]butan-2-one

Guidance literature:: (2R,4S,6R,8R,10S)-10-(tert-butyldimethylsilanyloxy)-2-(2-ethylprop-2-en-1-yl)-4-methoxy-8-(p-methoxybenzyloxymethyl)-1,7-dioxaspiro[5.5]undecane; With 4-methylmorpholine N-oxide; osmium(VIII) oxide; In water; acetone; tert-butyl alcohol; at 20 ℃; for 7h;

With sodium periodate; In methanol; water; at 20 ℃; for 1h;
DOI:10.1021/ol035848h

Reference yield:

: (R)-4-[(2S,4S,6R,8R,10S)-10-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-8-(4-methoxy-benzyloxymethyl)-1,7-dioxa-spiro[5.5]undec-2-yl]-2-methyl-3-oxo-butyric acid

: 201354-99-6
1-[(2S,4S,6R,8R,10S)-10-(tert-butyldimethylsilanyloxy)-4-methoxy-8-(p-methoxybenzyloxymethyl)-1,7-dioxaspiro[5.5]undec-2-yl]butan-2-one

Guidance literature:: With pyridine; In toluene; at 40 ℃; for 1h;
DOI:10.1002/anie.200502008

Reference yield:

: 201355-01-3
(4S,6R)-6-(t-butyldimethylsiloxy)-4-methoxy-8-nonen-2-one

: 201354-99-6
1-[(2S,4S,6R,8R,10S)-10-(tert-butyldimethylsilanyloxy)-4-methoxy-8-(p-methoxybenzyloxymethyl)-1,7-dioxaspiro[5.5]undec-2-yl]butan-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: Et₃N / diethyl ether / -78 - 0 °C

2.1: diethyl ether / 16.5 h / -78 - -20 °C

2.2: aq. H₂O₂; methanol / diethyl ether / 1 h / 20 °C

3.1: aq. HF / acetonitrile / 0.83 h / 0 °C

3.2: 1.17 g / HCl / diethyl ether; CH₂Cl₂ / 0.5 h / 20 °C

4.1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / -78 °C

5.1: aq. NMO / OsO₄ / acetone; 2-methyl-propan-2-ol / 20 h / 20 °C

6.1: 875 mg / NaIO₄ / methanol / 1 h / 20 °C

7.1: tetrahydrofuran; diethyl ether / 2 h / 20 °C

8.1: 1.53 g / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

With 2,6-dimethylpyridine; sodium periodate; N-methyl-2-indolinone; hydrogen fluoride; Dess-Martin periodane; triethylamine; osmium(VIII) oxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone; acetonitrile; tert-butyl alcohol; 8.1: Dess-Martin oxidation;
DOI:10.1039/b504148a