2,3-Dihydro-2-hydroxy-1H-isophosphindoline 2-oxide

Base Information

• Chemical Name: 2,3-Dihydro-2-hydroxy-1H-isophosphindoline 2-oxide
• CAS No.: 20148-17-8
• Molecular Formula: C₈H₉O₂P
• Molecular Weight: 168.132
• Mol file: 20148-17-8.mol

Synonyms:2-OXO-1,2-DIHYDROPYRIDINE-4-CARBOHYDRAZIDE;2-Hydroxy-isonicotinsaeure-hydrazid;2-hydroxypyridine-4-carbohydrazide;2-hydroxy-isonicotinic acid hydrazide;4-Pyridinecarboxylicacid,1,2-dihydro-2-oxo-,hydrazide;2-hydroxyisophosphindole-2-oxide;2-hydroxyisophosphindoline-2-oxide;

Chemical Property of 2,3-Dihydro-2-hydroxy-1H-isophosphindoline 2-oxide

Chemical Property:

• Melting Point: 156-158℃
• Boiling Point: 458.8±35.0 °C(Predicted)
• PKA: 2.37±0.20(Predicted)
• PSA: 47.11000
• Density: 1.32
• LogP: 1.97060

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Dihydro-2-hydroxy-1H-isophosphindoline 2-oxide

There total 7 articles about 2,3-Dihydro-2-hydroxy-1H-isophosphindoline 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5,6-Dibromo-2-oxo-2,3,4,5,6,7-hexahydro-1H-2λ5-isophosphindol-2-ol → 2-hydroxyisophosphindoline-2-oxide (20148-17-8)

Guidance literature:

With triethylamine; In acetone; for 240h; Heating;

DOI:10.1002/mrc.1260231110

Reference yield:

α,α'-dibromo-o-xylene (91-13-4) → 2-hydroxyisophosphindoline-2-oxide (20148-17-8)

Guidance literature:

With chloro-trimethyl-silane; ammonium hypophosphite; N-ethyl-N,N-diisopropylamine; Yield given. Multistep reaction; 1.) CH₂Cl₂, r.t., 2 h; 2.) CH₂Cl₂, 20 h, r.t.;

DOI:10.1016/0040-4039(96)01127-6

Reference yield:

2-hydroxy-1,3,4,7-tetrahydroisophosphindole-2-oxide (70179-65-6) → 2-hydroxyisophosphindoline-2-oxide (20148-17-8)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene;

DOI:10.1021/jo01328a060

upstream raw materials:

ortho-xylene-α,α'-diphosphonic acid

2-hydroxy-1,3,4,7-tetrahydroisophosphindole-2-oxide

α,α'-dibromo-o-xylene

o-Xylylene dichloride

Downstream raw materials:

2-(2-methyl-benzyl)-2,3-dihydro-1H-isophosphindole 2-oxide